In an era of dairy-avoidance, and a plethora of non-dairy substitutes, consumption of soy-based products is widespread.
For anyone considering, or on, a diet including significant quantities of soymilk, this paper might be of relevance.
Although not strictly thyroid-related, it is the milk substitute issue which makes it relevant - for some.
Am J Emerg Med
. 2021 Jan 27;S0735-6757(21)00058-9.
doi: 10.1016/j.ajem.2021.01.055. Online ahead of print.
The soymilk diet: A previously unknown etiology of acute pancreatitis
Ian S deSouza 1 , Alexander Lipsitt 2
Affiliations
• PMID: 33546956
• DOI: 10.1016/j.ajem.2021.01.055
Abstract
We present a case of daily, large ingestions of soymilk that likely led to acute pancreatitis. Soybean contains trypsin inhibitor that when ingested will reduce the activity of trypsin in the intestine. A decrease in intestinal proteolytic activity removes the negative feedback on the pancreatic acinar cells, leading to an inappropriate increase in intrapancreatic trypsin secretion. When trypsin activation exceeds the capacity of pancreatic secretory trypsin inhibitor, the subsequent cascade of events can lead to acute pancreatitis.
Keywords: Pancreatic secretory trypsin inhibitor; Pancreatitis; Soymilk; Trypsin inhibitor; Trypsinogen.
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