Low T3 identified in deaths from heart attack

[Bearo]

Our findings confirm the importance of testing thyroid function in these patients, as already recommended by the guidelines on diagnosis and management of [acute heart failure],” the researchers concluded. “In addition, future studies should be considered to evaluate the treatment of selected patients with [acute heart failure] who could benefit from a T3 replacement approach.”

Reference

De Matteis G, Covino M, Burzo ML, et al. Prognostic role of hypothyroidism and low free-triiodothyronine levels in patients hospitalized with acute heart failure. Intern Emerg Med. Published online January 2, 2021. doi:10.1007/s11739-020-02582

This appeared online today on Endocrinology Advisor

[helvella]

Thanks - interesting but, sadly, not surprising.

The abstract (only) of the actual paper is available here:

Prognostic role of hypothyroidism and low free-triiodothyronine levels in patients hospitalized with acute heart failure

link.springer.com/article/1...

[Bearo in reply to helvella]

Thanks, Helvella, I always have problems providing links!

[jimh111]

There have been a number of studies that have shown low T3 syndrome is associated with cardiac failure and death but it is not known whether low T3 is a cause or a protective mechanism.

[diogenes Remembering]

This paper of ours shows that there are two sorts of changes to thyroid function; one is protective (lower FT3) and the other is more serious (i.e. out of control). Open to download.

Thyroid Allostasis–Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming

July 2017 Frontiers in Endocrinology 8:163 DOI: 10.3389/fendo.2017.00163

Projects: Research Topic "Homeostasis and allostasis of thyroid function"Biomedical Cybernetics AQUA FONTIS StudyType 2 allostatic response of thyroid function as a cardiovascular risk factor. Complexity in Medicine: Practical Problems, Their Definitions, Models, and Solutions

Apostolos Chatzitomaris, Rudolf Hoermann, John Edward M Midgley, Johannes W. Dietrich et al

[Bearo]

I should add, in case anyone with low T3 gets unduly worried, that most of the heart attack deaths in the study I mentioned were over 80 years of age.