Relationship of FT3/FT4 ratio to cardiac mortality

[diogenes]

This paper looks at the FT3/FT4 ratio as a signal for cardiac failure. Joins in nicely with the one just posted.

Value of FT3/FT4 Ratio in Prognosis of Patients With Heart Failure: A Propensity-Matched Study

April 2022

Frontiers in Cardiovascular Medicine 9:859608 

DOI: 10.3389/fcvm.2022.859608L

Chuanhe Wang. Su Han Ying Li, Sun Zhijun

[LindaC]

When taking T3 only, can it have a significant negative impact?

[humanbean]

Link for the full paper :

frontiersin.org/articles/10...

[humanbean]

I've just checked the ratio of my last FT3/FT4 results and come up with :

4.81 / 15.3 = 0.314

Units for FT3 and FT4 are pmol/L.

I looked at the paper, but I can't see what classifies as a low ratio or a high ratio. Can anyone else find it?

[bookish in reply to humanbean]

Just below Table 1, under Results, Baseline Characteristics, it gives an 'optimal cutoff value' as 0.233 with low as 0.085-0.233 and high as 0.233-0.563. Not sure where this gets me. I am 0.226, because both FT3 and FT4 are abysmal, at 2.76 and 12.2! Cheers

[humanbean in reply to bookish]

Thanks. I can't say I'm much wiser though, which is often the case with research papers.

[diogenes Remembering in reply to humanbean]

I would say that the basis of the finding is that increased risk of cardiac mortalitiy often means that the patient is already ill to some extent because of cardiac strain and therefore will show the lower FT3 typical of nonthyroidal illness and thus a changed FT3/FT4 ratio

[Molly161018]

Please can you explain the conclusion in simple terms...? I've looked at the paper but doesn't mean much to my simple brain...