Possible treatment for Acute respiratory distress syndrome in Covid-19

[lynmynott]

Doctors Tim Rich (Essentia) and David Ingbar (University of Minnesota) have a COVID-19 therapy in Phase 2 trials that might prevent or undo the COVID-19 complication you never want to hear about.

Rich and Ingbar autopsied H1N1 victims in 2009 and discovered that the affected lungs lacked T3. T3 reduces inflammation and helps epithelial cells in the lungs absorb fluids.

Acute respiratory distress syndrome (ARDS) is a complication that can be fatal in Covid-19.

The doctors received approval to test their ARDS therapy late last year and have tested T3 on two patients who survived Covid-19 after the therapy. It's not clear yet whether it would work on other patients.

The FDA have now given approval to test T3 on further Covid-19 patients so we will soon see.

This may be a very important breakthrough for Covid-19 patients.

For more information go here:

bgr.com/2020/11/02/coronavi...

[amala57]

Thank you. That is so interesting. Look forward to hearing more about this.

[Rapunzel]

The researchers are also working on creating a patented T3 formulation...

I bet they are. Deep joy. But not a reason to stop hands, face, space, no?

Anything proving the safety of T3 to gainsay older medics with ingrained attitudes to T3 is to be welcomed. Top find, Lyn and thanls for sharing.

[Angel_of_the_North]

It's interesting, but I wonder if the low T3 is the same low T3 that you get with severe illness. However, let's hope it works so that T3 isn't seen as the devil incarnate. I also thought that the American MATH+ protocol worked, but the more the merrier.

[jimh111]

There is a similar study ongoing clinicaltrials.gov/ct2/show... with intravenous high dose T3. The use of inhaled T3 may be a better strategy as it delivers the drug primarily where it may be useful.

The effects of thyroid hormones in COVID-19 is complex. There is evidence that T4 (from the thyroid or from tablets) facilitates the entry of SARS-Cov-2 into the cells via 'integrin' which T4 attaches to. Thus lowering T4 by taking T3 might reduce SARS-Cov-2 infection. On the other hand 'low T3 syndrome' is protective against hypoxia and stroke which can be consequences of severe COVID-19. On the other hand (if you've got 3 hands!) T3 can help with recovery. It may be that the timing of T3 administration is crucial, low T3 initially followed by high T3 in recovery. These studies do not consider timing and so may not be successful. At least T3 is in the news.

[helvella Administrator in reply to jimh111]

Whereas this trial is listed on that same site, in case anyone is interested:

clinicaltrials.gov/ct2/show...

[foxglove]

All very well, but will it deplete the T3 stocks that are needed for thyroid sufferers?

[TaraJR in reply to foxglove]

Or the powers that be might end up desperate to source T3 cheaply?! We can but hope.

[lynmynott Partner Thyroid UK in reply to TaraJR]

That sounds like a good idea! Fingers crossed!

[foxglove in reply to TaraJR]

As is said "Hope springs....."

[Ruste]

Thanks for sharing great find.