Should I still be looking to have lower TSH - Thyroid UK

Thyroid UK

137,641 members161,422 posts

Should I still be looking to have lower TSH

Katrina999666 profile image
10 Replies

Initially GP blood draw

TSH was 4.21 (0.27-4.2)

T4 was 13.5 (10-22)

Antibodies 168.71 no range given

started on 25mcg Levothyroxine

6 weeks later results GP blood draw

TSH was 4.21 (0.27-4.2)

T4 was 15.9 (10-22)

Felt awful so decided to challenge the dosage and GP increased it to 50mcg

7 weeks later results GP blood draw

TSH was 1.66 (0.27-4.2)

T4 was16.1 (10-22)

Whilst the TSH has dropped on the increased dose is it enough? as it is only 50.93 through range.

I do feel better than I did on the low 25 dose for sure but, I wonder if I could feel better on a slightly increased dose.

All bloods were taken 8.30am and fasting as well as Levothyroxine dose 26 hours previously.

I am taking Vit D with K oral spray and vitamin B complex which I also stopped 10 days prior to blood draw.

Any opinions gratefully received thank you

Written by
Katrina999666 profile image
Katrina999666
To view profiles and participate in discussions please or .
Read more about...
10 Replies
SlowDragon profile image
SlowDragonAdministrator

Just testing TSH and Ft4 is inadequate

For full Thyroid evaluation you need TSH, FT4 and FT3 tested. Also EXTREMELY important to test vitamin D, folate, ferritin and B12

Low vitamin levels are extremely common, especially as you have autoimmune thyroid disease (Hashimoto's) diagnosed by raised Thyroid antibodies

Ask GP to test vitamin levels or test privately

Good you did test as Recommended on here...... as early as possible in morning and before eating or drinking anything other than water. Last dose of Levothyroxine 24 hours prior to blood test.

Private tests are available as NHS currently rarely tests Ft3 or all relevant vitamins

List of private testing options

thyroiduk.org/getting-a-dia...

Medichecks Thyroid plus vitamins including folate (private blood draw required)

medichecks.com/products/thy...

Thriva Thyroid plus antibodies and vitamins By DIY fingerpick test

thriva.co/tests/thyroid-test

Thriva also offer just vitamin testing

Blue Horizon Thyroid Premium Gold includes antibodies, cortisol and vitamins by DIY fingerprick test

bluehorizonbloodtests.co.uk...

If you can get GP to test vitamins then cheapest option for just TSH, FT4 and FT3

£29 (via NHS private service ) and 10% off if go on thyroid uk for code

thyroiduk.org/getting-a-dia...

monitormyhealth.org.uk/thyr...

Katrina999666 profile image
Katrina999666 in reply to SlowDragon

These are GP results have done Medichecks well woman and will do again but want to continue to get NHS to test as well as and they as you know don't usually test T3 or vitamins unless absolutely necessary in their opinion.

SlowDragon profile image
SlowDragonAdministrator

Previous post

healthunlocked.com/thyroidu...

FOLATE-SERUM 10.69 > (3.89)

VITAMIN B12 ACTIVE 48.9 > (37.5)

VITAMIN D 39.5 (50-175)

TSH 3.1 (0.27-4.2)

FREE T3 3.97 (3.1-6.8)

FREE THYROXINE 15.7 (12-22)

THYROGLOBULIN ANTIBODIES 14.6 < (115)

THYROID PEROXIDASE 127 < (34)

shows low vitamin D and low B12

Active B12 Under 70 is considered suspect

Did GP test for Pernicious Anaemia?

Are you now taking daily good quality Vitamin B complex?

Did you do coeliac blood test and are you on strictly gluten free diet?

Katrina999666 profile image
Katrina999666 in reply to SlowDragon

These results are from Medicheck .

No GP didn't do pernicious anaemia blood test.

Yes taking good quality B complex as advised and stopped prior to blood draw by GP

Yes taking oral Vitamin D K.

Haven't done Coeliac test next on list.

Not strictly but trying to eliminate Gluten.

I was trying to ascertain whether the lowered GP results TSH and increased every so slightly T4 were adequate or whether I should be pushing to have another increase?

SlowDragon profile image
SlowDragonAdministrator in reply to Katrina999666

If not eating high level of gluten there’s not much point testing for coeliac

Highly likely you need to increase dose levothyroxine up to 75mcg

Might need to get TSH, Ft4 and Ft3 tested privately first

See GP and request 25mcg dose increase ....see if you can get dose increase

Print out these guidelines to take along ...perhaps only produce them if GP refuses

guidelines on dose levothyroxine by weight

Even if we don’t start on full replacement dose, most people need to increase levothyroxine dose slowly upwards in 25mcg steps (retesting 6-8 weeks after each increase) until on or near full replacement dose

NICE guidelines on full replacement dose

nice.org.uk/guidance/ng145/...

1.3.6

Consider starting levothyroxine at a dosage of 1.6 micrograms per kilogram of body weight per day (rounded to the nearest 25 micrograms) for adults under 65 with primary hypothyroidism and no history of cardiovascular disease.

gp-update.co.uk/Latest-Upda...

Traditionally we have tended to start patients on a low dose of levothyroxine and titrate it up over a period of months. RCT evidence suggests that for the majority of patients this is not necessary and may waste resources.

For patients aged >60y or with ischaemic heart disease, start levothyroxine at 25–50μg daily and titrate up every 3 to 6 weeks as tolerated.

For ALL other patients start at full replacement dose. For most this will equate to 1.6 μg/kg/day (approximately 100μg for a 60kg woman and 125μg for a 75kg man).

If you are starting treatment for subclinical hypothyroidism, this article advises starting at a dose close to the full treatment dose on the basis that it is difficult to assess symptom response unless a therapeutic dose has been trialled.

A small Dutch double-blind cross-over study (ArchIntMed 2010;170:1996) demonstrated that night time rather than morning dosing improved TSH suppression and free T4 measurements, but made no difference to subjective wellbeing. It is reasonable to take levothyroxine at night rather than in the morning, especially for individuals who do not eat late at night.

BMJ also clear on dose required

bmj.com/content/368/bmj.m41

bestpractice.bmj.com/topics...

Katrina999666 profile image
Katrina999666 in reply to SlowDragon

I've already purchased Medi check Thyroid panel. How do we know when we are near full replacement dose? I know the guidelines say dosing for weight but they are guidelines I'm a bit confused as to how I know when I have reached optimal. I felt awful when I was first put on 25mcg so after the 8 weeks I argued that it should be increased. I do feel better than I did now that I am on the 50mcg.

SlowDragon profile image
SlowDragonAdministrator in reply to Katrina999666

Unless extremely petite you are likely to need to increase slowly upwards in 25mcg steps until on at least 100mcg

Weigh yourself in kilo x 1.6 = likely dose you might need.

So people need higher dose, especially if lactose intolerant

Katrina999666 profile image
Katrina999666 in reply to SlowDragon

On weight calculation I should be on 118 so rounded up 120 so I think I will take the medicheck to see what my T3 is and then come back and post the result to ask for more advice which is always greatly received and appreciated.

Stourie profile image
Stourie in reply to Katrina999666

You will know when you are on the correct dosage when you feel good with all or most of the symptoms gone. Wishing you well. Jo. Xx

Katrina999666 profile image
Katrina999666 in reply to Stourie

Thank you

You may also like...

TSH lower than before, so should I ask for medication?

recent blood test results. Sorry for the long post. TPO 94.8 (<34) TgAb 492 (<115) TSH 3.17...

Could someone please advise on my results

Started on Levothyroxine 25mcgs 9 weeks ago after GP results TSH 4.21 (0.27-4.2) T4 13.5 (10-22) No

On Thyroxine - 8 weeks bloods shows TSH has dropped but still feel dreadful.

50mg Levothyroxine for 8 weeks after private bloods showed the following; TSH 6.51 (R 0.27-4.2) T3

new results, should i push for an increase?

my doc doesnt increase my dose? my last results 2 months ago were: tsh: 0.66 (0.27-4.2) t4: 17.1...

TSH lower but still having many symptoms

am at risk of developing hypothyroidism so have blood tests every year. It was 3.8 in July but my...