By chance, happened across this Freedom of Information Request from Thyroid Ninja. As the issue of break-marks, espcially on liothyronine, has been raised many times, I though it possibly interesting. (Bit of a long read - you can probably skip lots of it.)
Thyroid Ninja 4 February 2019
Dear Medicines and Healthcare products Regulatory Agency,
All UK licenced liothyronine thyroid tablets are 20mcg. The Patient Information Leaflets of all these tablets now state that for doses smaller than 20mcg:
1. The tablet must be dissolved (for periods of time between 5 & 10 minutes depending on manufacturer) and a portion of the liquid drawn up & dispensed.
2. The remaining liquid must be disposed of. As most patients are on multiple doses per day, this is wasteful of medication & financial resources.
whatdotheyknow.com/request/...
(Of course, Thyroid Ninja could be a member here! )