New paper showing advantage of T4 + T3-sulphate rather than T4 + T3 alone for combination therapy

[diogenes]

This paper at present in preliminary abstract form investigates using T3-sulphate rather than T3 for combination therapy:

Front. Endocrinol. | doi: 10.3389/fendo.2019.00826

TREATMENT OF HYPOTHYROID PATIENTS WITH L-THYROXINE (L-T4) PLUS TRIIODOTHYRONINE SULFATE (T3S). A PHASE II, OPEN-LABEL, SINGLE CENTRE, PARALLEL GROUPS STUDY ON THERAPEUTIC EFFICACY AND TOLERABILITY

Ferruccio Santini1*, Giovanni Ceccarini1, Caterina Pelosini1, Monica Giannetti1, Ilaria Ricco1, Giorgia Querci1, Enzo Grossi2, Giorgio Saponati3 and Paolo Vitti1

[jimh111]

Thanks, the doses seem a bit strange but no doubt will be clearer when the full paper is published. Here is the link frontiersin.org/articles/10... .

[helvella Administrator in reply to jimh111]

Might be worth a look here:

clinicaltrialsregister.eu/c...

[jimh111 in reply to helvella]

Thanks, I'll wait for the paper to be published. It seemed strange that 25 mcg L-T4 was replaced with 40 mcg T3S but perhaps T3S has very poor absorption and this is what gives stable serum T3 levels, that it is absorbed slowly.

[helvella Administrator in reply to jimh111]

T3S has a molecular weight just over 30% greater than that of T3. Which by simple arithmetic, and molecule for molecule, would make 25 micrograms of T3 about equivalent to about 32 micrograms of T3 Sulphate. So only another eight micrograms to justify.

[jimh111 in reply to helvella]

Yes but L-T3 is about 3x as potent as L-T4 on a mcg by mcg basis. However, there may be other factors involved, will await the full paper.

[jimh111]

Full paper now available Treatment of Hypothyroid Patients With L-Thyroxine (L-T4) Plus Triiodothyronine Sulfate (T3S). A Phase II, Open-Label, Single Center, Parallel Groups Study on Therapeutic Efficacy and Tolerability .