TREATMENT OF HYPOTHYROID PATIENTS WITH L-THYROXINE (L-T4) PLUS TRIIODOTHYRONINE SULFATE (T3S). A PHASE II, OPEN-LABEL, SINGLE CENTRE, PARALLEL GROUPS STUDY ON THERAPEUTIC EFFICACY AND TOLERABILITY
Ferruccio Santini1*, Giovanni Ceccarini1, Caterina Pelosini1, Monica Giannetti1, Ilaria Ricco1, Giorgia Querci1, Enzo Grossi2, Giorgio Saponati3 and Paolo Vitti1
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Thanks, I'll wait for the paper to be published. It seemed strange that 25 mcg L-T4 was replaced with 40 mcg T3S but perhaps T3S has very poor absorption and this is what gives stable serum T3 levels, that it is absorbed slowly.
T3S has a molecular weight just over 30% greater than that of T3. Which by simple arithmetic, and molecule for molecule, would make 25 micrograms of T3 about equivalent to about 32 micrograms of T3 Sulphate. So only another eight micrograms to justify.
Full paper now available Treatment of Hypothyroid Patients With L-Thyroxine (L-T4) Plus Triiodothyronine Sulfate (T3S). A Phase II, Open-Label, Single Center, Parallel Groups Study on Therapeutic Efficacy and Tolerability .
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