Paper on effects of T3 therapy: This paper... - Thyroid UK

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Paper on effects of T3 therapy

diogenes profile image
19 Replies

This paper describes a lack of relationship to cancer or mortality for T3 patients.

Clinical ThyroidologyVol. 32, No. 12 Hypothyroidism

Triiodothyronine Treatment of Hypothyroidism Does Not Increase Overall Cancer Incidence and Mortality

Yanrui Huang and Haixia Guan

Published Online:8 Dec;32....

19 Replies
shaws profile image

Thanks for your link diogenes. I just hope - against hope - that the professionals in the UK take notice of this research. I think they ignore most of what is published.

LindaC profile image

Thank you diogenes - what with all of 'their' dire warnings of everything 'wrong' with T3 - this is good to know. It's getting close, so 🌲 Season's Greetings 🌲 and a huge thank you for all that you and your colleagues do. 💚

TaraJR profile image

Here's a link to the full paper

PaulRobinson profile image
PaulRobinson in reply to TaraJR

Many thanks Tara!

PaulRobinson profile image

Thanks for this. Is there a link to the full paper?

Articles like this are exactly what those thyroid patients on T3 need to counter the scaremongering from anti-T3 doctors and endocrinologists.

If there is a full link that would be wonderful.

Have a safe, and healthy Christmas!

Best wishes, Paul

FancyPants54 profile image
FancyPants54 in reply to PaulRobinson

TaraJR Gave the full link above you Paul.

While I have you here 😉 do you have any links to papers which support the use of T3 in patients with arrhythmia, namely atrial fibrillation? I have recently added a little T3 to my Levo and my heart loves it, it calms down straight away and I can feel it more at night when the T3 wears off. But of course the cardiologist tried to frighten me about it a couple of years ago, which made me stop the T3 at the time and now the Endo. (private) has said I can't have more than 20mcg a day and must not have a TSH below 0.5. I don't think 20 a day will be enough as on 15 at the moment and it's nothing like good enough, in fact worse than T4 alone.

I've found the odd paper about low T3 causing AF, but not much. I need more ammunition.

I also have the Dio2 gene defect from one parent.

I hope you are keeping well and fit and happy. Merry Christmas to you and your family. (Sue from your old forum.)

PaulRobinson profile image
PaulRobinson in reply to FancyPants54


I'm not sure I do have specific papers on this. However, one of the very common things I have seen over the years is for heart rate and BP to come down as well as cholesterol when someones T3 levels have become healthier for them.

However, I've just done a little searching. You can check these articles out:

I hope this helps.

Best wishes, Paul

FancyPants54 profile image
FancyPants54 in reply to PaulRobinson

Thank you so much for these links Paul. I shall save those and digest them later (putting decorations up now) because I am going to need to fight my corner. When my Afib went persistent (I had random, hideously violent bouts for 6 years before (although nothing whilst following your T3 only protocol despite doctors freaking out) it was so much better to live with but it gave me a fast heart rate. I have to take beta blockers to lower it into the 90's resting. It used to be in the 70's. It took the NHS 11 months before they tried a cardioversion on me and it did work, my heart beat was normal for several weeks but my heart rate remained high. And it's stayed there. However, the first week I reintroduced a little T3 my heart rate dropped to low 80's and most of the time I just can't feel the beats. I notice them at night when T3 is getting lower. As with all hormones, there's a grace period where symptoms abate bu then return quite quickly when a dose increase is needed and so far, for various reasons I've had to stay at 15mcg T3 a day with Levo and heart rate went back up.

Personally I'm convinced the hypo status of my body is the reason for the AF, or it's persistent state anyway. It makes me more determined to explore all avenues to escape it. T3 feels good when it goes in. Trouble is it seems to have really knocked my T4 down, which is odd. I expected some reduction when introducing T3, but the drop is much bigger than I expected, thus removing some conversion opportunities so I've ended up lower in both T's. This is why I know I will need to be able to fight my corner for more T3 in my Afib state.

Thanks again Paul.

PaulRobinson profile image
PaulRobinson in reply to FancyPants54

p.s. Merry Christmas to you too Sue! I am keeping fit and well thanks. Not sure about happy! This year!!!! Well, what can you say? I'm looking forward to saying goodbye and good riddance to 2020. Roll on the vaccines.

The dogma they are using in capping the T3 and enforcing the TSH is just utterly broken. It is also a postcode lottery. I'm still in 60 mcg T3 and my TSH is very low but I ensure it isn't too low if I have to have a blood test. Luckily my GP only tests me when he has to fill the form in once a year - he knows better than to put any faith in FT3 or TSH now.

FancyPants54 profile image
FancyPants54 in reply to PaulRobinson

I'm so happy that you can still get all the T3 you need. They seem to want to keep us sick.

And yes, 'happy' isn't a word we've had much cause to use this year, but you know what I mean. Fortunately I'm OK without a lot of people around, but I know others can't bear being isolated.

PaulRobinson profile image
PaulRobinson in reply to FancyPants54

Yes, it has just got worse though hasn't it. So difficult. Take care Sue.

Hillwoman profile image
Hillwoman in reply to FancyPants54

FancyPants, you might want to search through Tania SS's blog posts. I remember a couple of her recent ones looked in depth at research that examined this question, and the conclusions should reassure you. Sorry I don't have time to find the relevant ones, but here's the link to the site:

Hillwoman profile image
Hillwoman in reply to Hillwoman

Here we are - found it quickly after all.

FancyPants54 profile image
FancyPants54 in reply to Hillwoman

Yes, thank you. I have this, I probably got it from her. I printed it out. It's very reassuring. Except my T3 is lowish in range, never below, but I don't think that matters. If it's low for me (and given how little energy I have it really is very low for me) the effects will be the same. It's very good, the only one I've found like it. It put's it into layman's terms for one thing.

Alanna012 profile image


jimh111 profile image

Interesting. There has been a lot of controversy about thyroid hormone and cancer. It seems to be a very complex subject with a large degree of prejudice against T3. Caution should be exercised when using these sort of retrospective studies. It is so difficult to get any form of T3 prescribed that it is reasonable to assume that patients who receive it are on the whole sicker than the standard hypothyroid patient. The two groups are not starting from the same place.

The following stretches my knowledge so don't assume there is a level of expertise! I will use vague terms so I don't imply precision.

As well as having genomic actions (T3 binding to receptors that invoke DNA action) T3 and T4 also have non-genomic actions - I think of them as little jobs they do on the side. Amongst these is T4 binds to the cell membrane and the integrin that connects cells. T3 tends not to do this.

As a consequence T4 can facilitate the entry of SARS-CoV-2 into cells . So, patients with low levels of T4 (because they are on T3) may have a degree of protection from COVID-19 infection.

As regards cancer, T4 can play a similar role in 'hard' cancers which may respond to treatments that lower T4 levels by giving T3 theoncologist.onlinelibrary... .

Thus, T3 (by lowering T4 levels) may be protective against both COVID-19 and some cancers. On the other hand there is some evidence that low T3 syndrome is protective during some conditions such as stroke. This protective effect of low T3 syndrome would logically be inhibited in patients on T3 therapy. This is very complex, when T3 helps and when it doesn't.

Most of these effects are rare or subtle. For patients like myself T3 allows a reasonably normal life and I am able to go for long walks and play squash and badminton. The benefits of this activity vastly outweighs the relatively minor direct effects of T3 on various conditions. There's a need to keep things in perspective and make sure doctors keep a sensible balance. Without T3 many patients would not be able to stand their ground and maintain a reasonably healthy lifestyle.

TSH110 profile image
TSH110 in reply to jimh111

Didn’t Broda Barnes do a large study of cause of death in patients taking NDT when that was the only medication available and he also found it was protective against a whole range of things that kill. We talk as though T3 has hardly been used for treating hypothyroidism but it has a very long history of use far longer than synthetic T4 . Maybe researchers need to look to the past for evidence it is protective. It seems patently obvious to me it is important for health or why would a healthy thyroid bother to make it? I bet these crazy endocrinologists would like to manufacture a synthetic thyroid that only made T 4 and transplant it into as many people as possible because they think Mother Nature is a poor designer, and far inferior to them wasting time and energy on producing a useless thing like T3 🙄 their testing protocol show what little regard they accord it.

LAHs profile image
LAHs in reply to TSH110

You make a very good point about researchers not looking into the past for data which may guide them in their research. This happens in many fields of research not just medicine. The act of reading and reproducing the early more basic stuff doesn't look "cool". Researchers only want to look forward and do the new exciting stuff with their new technologies. A lot of time, energy and money is wasted ignoring history and reinventing wheels.

diogenes profile image
diogenes in reply to LAHs

When publishing a paper some time ago (as single author) I was criticised by a reviewer as to why some of the references were nearly 20 years old. Implying of course that more modern studies were intrinsically superior. I had to point out that accurate and well founded studies had the primacy of publication regardless of date, but the rule of quoting primary publication owing to date was the rational and courteous thing to do.BTW if anyone expects that, if the T3 revolution takes hold, there will be no weeping and wailing and sackcloth & ashes from those gurus who spent their lives railing against it. The wrong ideas will be quietly smothered and invisibly depart as if they never were. I've had that experience three times in my career, where one opponent died after unsuccessfully trying for 20 years to get the basis of FT4 and FT3 tests undermined, another whose group were incapable of properly examining and commenting on the tests, yet had multiple papers trying to do exacly that and when challenged simply brought more suffocating mental cottonwool to justify themselves, has retired and the papers are no longer referred to, and yet another who using a novel technique nevertheless failed to follow the rules of valid testing has now faded from sight and gone on to another area he can mismanage. That is the way of things fortunately - the truth suffocates the liars.

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