Hello to everyone,
Are there people using CYNOMEL FROM SANOFI (FRANCE) how are you feeling on this brand? How much mcgs are you using?
I read this is a pretty weak brand compared cytomel from Pfizer or cynomel from Mexico, and about the same to tiromel and maybe thybon...
I read that tiromel is weaker than Mexican cynomel (at last - 25%).
I am curious about to know your experience and feedbacks on cynomel sanofi or other brands.
Thank you
I take that brand and generally feel good on it. I take half a tablet in the morning 12.5 and my TSH is usually 0.03 and that makes my dr think I am over medicated.
If I don't take it my energy drops down drastically and I feel tired all the time and unenthusiastic and difficulty in concentrating.
Best wishes in making your choice and hope all goes well for you.
I think I've tried just about every brand there is except Cytomel from the US. And, frankly, I didn't find much difference in any of them. The only one that seemed a little weak to me was the one that comes in doses of 75 mcg at a time - can't remember the name… The others are pretty much of a muchness, as far as I'm concerned.
I read many reports about the fact that some brand are weak... And according to same siteweb, like thyroidrt3.com, cynomel sanofi is very weak.. For me this information are very important because even if on 100mcg cynomel sanofi i still am hypo.........
I still have high rt3, very high.
So could i think it is for rt3..?
I know there are a lots of differents informations about rt3.. I studied a lot.
But it is a fact that there are a lot of people who need less t3 than they used during the "clearing process of rt3", abd they report to be much better after clearing it....
So, wich is the true story about rt3 and his real impact on metabolism???
PERSONALLY I HAVE A VERY ODD SITUATION DUE TO A LABORATORY MISTAKE DONE BEFORE STARTING ANY THYOIDS...! 😠.
I DISCOVERED MY RT3 WAS LOW, AND THE LABORATORY HAVE TO ME A WRONG RANGE!!
SO, IN THIS YEAR I WAS TRYING TO DO THE CLEARING INCREASING T3, ALSO AT 100MCG I STILL HAD A VERY LITTLE T4 PRODUCTION ABS VERY VERY HIGH RT3, THIS TIME THE VALUE IS CORRECT! SO I CAUSED MY RT3 TO BE MOSTROUSELY ELEVATED USING T3 TO CLEAR IT......
In this scenario if i try to decrease t3 and introduce a little t4 i am very worse!!
So i am finding a way to switch from t3 only to t4/t3...
But 100mcg of cynomel aren't enough for me...
P. S. I see i lost a lot of hairs last months on t3 only.
There are many, many causes of high rT3, and only one of them has anything to do with the thyroid. Taking high doses of T3 is not a 'cure' for high rT3. Cutting out T4 will lower your rT3 of course, because it can only come from T4. But, that doesn't mean you have 'cured' it.
rT3 is inert, so doesn't have any direct effect on metabolism. It only stays in the body for a couple of hours before being converted to T2. rT3 is one total red herring!
For causes of high rT3 have a look at this:
Conditions that contribute to increased Reverse T3 levels include: Chronic fatigue, Acute illness and injury, Chronic disease, Increased cortisol (stress), Low cortisol (adrenal fatigue), Low iron, Lyme disease, Chronic inflammation. Also selenium deficiency, excess physical, mental and environmental stresses. Also Beta-blocker long-term use such as propranolol, metoprolol, etc. Physical injury is a common cause of increased RT3, also illnesses like the flu. Starvation/severe calorie restriction is known to raise RT3. Diabetes when poorly treated is known to increase RT3. Lyme disease. Cirrhosis of the liver. Fatty liver disease. Any other liver stress Renal Failure. A fever of unknown cause. Detoxing of high heavy metals.
healthunlocked.com/thyroidu...
So, I would suggest you look at some of those things to find out why your rT3 is high, and take a dose of T3 that actually suits your needs. But, I have to say that high rT3, in itself, is not 'an issue', as thyroidrt3.com says it is. I find that site rather dubious.
Maybe i wasn't enough clear...
Before trying any thyroids i didn't have any rt3 issue!!! The laboratory gave to me a wrong result.
Than my doctor gave to me t3 only due to rt3...
But after 1 year i discover that I didn't have any rt3 issue before starting t3 therapy... And t3 made my rt3 really high..
So now i want to switch from t3 to t4/t3 but i can't because if i added r t4 now even lower dose, it will be converted to rt3 due tge fact that tsh suppressed.
Thank you, i know very well about rt3, i study many studies, there are different study about in different way.
I need help to switch to t4/t3 effectively.
And the way to slow reduce t3 abs slowly increase t4 now is the worse way.
Before trying any thyroids i didn't have any rt3 issue!!! The laboratory gave to me a wrong result.
What do you mean by 'trying any thyroids'? You mean being diagnosed and put on levo? How do you know you didn't have high rT3 before then? What difference does having the wrong result make? rT3 is irrelevant as you have been told over and over again on here. It's not even worth doing the test.
You haven't given us any other results apart from rT3, so what was your FT4 level?
Than my doctor gave to me t3 only due to rt3...
So, your doctor doesn't understand rT3, either.
But after 1 year i discover that I didn't have any rt3 issue before starting t3 therapy... And t3 made my rt3 really high..
Yes, that can happen. So, why don't you just stop or reduce your T3?
So now i want to switch from t3 to t4/t3 but i can't because if i added r t4 now even lower dose, it will be converted to rt3 due tge fact that tsh suppressed.
TSH has absolutely nothing to do with rT3. Having a suppressed TSH does not mean that your T4 will be converted to excess rT3. There will always be some T4 converted to rT3 and some to T3 - about 50/50. But it is nothing to worry about. High rT3 is never, ever, anything to worry about.
Thank you, i know very well about rt3, i study many studies, there are different study about in different way.
You obviously haven't been reading the latest research on rT3. Understanding of the subject has evolved. We now know that it's nothing to worry about. It doesn't block T3 receptors as used to be thought. It is inert, as I said before, and doesn't affect metabolism.
I need help to switch to t4/t3 effectively.
That I understand. But, that is not what you have been asking. And, it really isn't important about the different strengths of different brands of T3, because whatever the brand, you just adjust the dose until you find what suits you. Actually, you're lucky to be able to get any T3 at all! Not many of us can afford to be picky.
Just write a new post giving your latest blood test results, with ranges, and your present dose of T3 and ask for help with switching to T4/T3. No-one is going to be able to tell you exactly what to do, because we all react differently, but people can advise you how to go about it.
Above all, try not to get side-tracked into a long, pointless discussion on rT3. It's irrelevant! 
Before to start any thyroids i Mena before to start any therapy for my hypothiroidism.
I try to be more specific ;
1.I DIDN'T HAVE HIGH RT3 BEFORE TO START THYROID HORMONES ;
- I JUST RUNNED MY THYROID TEST, TSH, FT3, FT4, RT3, ANTIBODY...
I had tsh 3.5
Ft3 3.3 2.2-4.4
Ft4 1 0.89-1.86
Rt3 0.54 0.10-0.24 *BUT THEN WE DISCOVERED THAT THIS RANGE FOR RT3 WAS A MISTAKE AND AFTER 1 YEAR - IN THE MEANWHILE I STARTED T3ONLY- THE LABORATORY SAID TO US THE CORRECT RANGE WAS 0.50-0.95!! So i didn't have high rt3.
But of course taking t3 made higher and higher my rt3, like 2.5 0.50-0.95! Because even if my tsh is suppressed, i still produce some t4 that is converted faster to rt3 due to exogenous t3 (I HAVE A DEGREE IN BIOLOGY, AND STUDIED A LOT ABOUT 😉).
-RESEARCHERS SHOW THAT WHEN TSH IS SUPPRESSED, ADMINISTRATION OF T4 OR T3 INCREASE THE CONVERSION OF T4 TO RT3 AND NOT TO T3.
Pease, if you say that isn't in this way, show my "the studies"... It is phisiology.
- rt3 has is specific receptor in citoplasma!! And some studies show it slow down the metabolism, and adding t3 revert the metabolic state..
Please if you say rt3 do nothing at all, show the studies and researchers...
- how can you explain that a lot of people if having high rt3 are so bae!? And after clearing it they are MUCH BETTER AND OFTEN NEED LESS T3?
Please explain to me this fact.
I am open mind, but if Someone speak about biology, phisiology etc.. Have to give explanation supported by research and studies about.
-----
2. Taking t3 gave me evident improvements.
But, in according to the fact we discovered i DIDN'T have any high rt3 before to start t3 (i have never used t4 only or t4/t3).. It is possible i can be better on t4/t3 than t3 only.
I don't think t4 is just a prohormone, it has different fuction than t3 in some tissues and organs, some people go better with t3 +t4 and some with t3, but we can't say t4 is just a prohormone....
So i want to go back, SWITCHING FROM T3 TO T4/T3, why?
Because i am in a situation where due to high exogenous t3(100mcg cynomel) i have high rt3.. But you say rt3 is nothing, okay..
If so, how to explain That i tryed to lower of 6.25 mt t3 adding some t4(25mcg,because 1mcg t3 is about 3.5mcg t4) and I WAS WORSE!
NOW I STOPPED T4 FROM 6DAYS, AND I AM TAKING AGAIN T3ONLY, 100mcg BUT I AM VERY WORSE YET!
IT IS PROBABLY BECAUSE INTRODUCING T4 WITH SUPPRESSED TSH AND HIGH EXOGENOUS T3 IS A PASS FOR HIGH RT3 THAT SLOWDOWN THE METABOLISM..
Of course i didn't have the true and i want to understand, but.. Please i am very happy if you can use scientific arguments about the rt3.. And the fact that even with suppressed tsh wi convert t4 in t3.
Because i studied differents things 😅🤔.
And one study shown that rt3 is inversely correlate with tsh... 😅
Please could you send me the last research about??thank you.
Dawid, it doesn't matter how specific you are, the reply is the same: rT3 is irrelevant. High levels of FT4 can cause more T4 to be converted to rT3 than T3 causing over-range levels of rT3. High levels of FT3 can do the same. So, you either reduce the T4 or you reduce the T3.
If so, how to explain That i tryed to lower of 6.25 mt t3 adding some t4(25mcg,because 1mcg t3 is about 3.5mcg t4) and I WAS WORSE!
Well, that doesn't sound difficult to explain, going from 100 mcg T3 to 6.25 mcg and adding in 25 mcg is pretty much guaranteed to make you feel worse. What a terrible shock to the system.
As you've never been on T4 only, we have no idea how well you convert. And it's meaningless to say that 3.5 mcg T4 = 1 mcg T3 if you can't convert the T4.
And now you've gone back to 100 mcg T3! Your body must think you've gone raving mad. It's insane to swop and change like that. Hardly surprising you feel worse.
IT IS PROBABLY BECAUSE INTRODUCING T4 WITH SUPPRESSED TSH AND HIGH EXOGENOUS T3 IS A PASS FOR HIGH RT3 THAT SLOWDOWN THE METABOLISM..
But, you weren't on a high dose of exogenous T3 when you introduced the T4. You'd reduced it to 6.25 mcg.
But, let's look at this from a different angle: what, exactly, do you think these high levels of rT3 are doing to you? Why are you so worried about them?
Although, to be honest, I don't think there's really much point in your replying. You, I and many other people have been over and over the same ground in your past four posts. You have rejected everything that has been said to you - including what has been said by our resident physiological biochemist, you think your qualifications are superior to his. Frankly, I don't think there's anything more to be said on the subject, because whatever is said you will just call it stupid. So, I'm bowing out of this discussion, hoping I never get sucked in again. Good luck.
I wrote i decreased my total 100mcg t3 of 6.25 mcg and added +13mcg t4!!!!
SO I TOOK FOR 8 DAYS 93mcgt t3 / 13 t4. And i was very worse untill now even if i stopped t4 and reintroduced +6.25 t3 like before.
Now is clear??
Really do you think i could go from 100 mcg t3 to 6.25?😳.
Now. How you can explain allbi wrote above, in my past post?
Please.
Your chemistry can say what he wants, but we have to study and understand the scientific studies. Not opinion, and above i asked you some question, if you or your chemistry can take me good studies about i am very happy, because i just want to better understand.
OK, so your English isn't very good. You may have thought you said that, but in actual fact you didn't. What you mean is you reduced your T3 BY 6.25 mcg.
Diogenes doesn't just give opinions, he is a researcher, and he has posted papers on this subject. So, I suggest you go through his posts and responses on his profile, and see what he says. But, as I said, I'm finished with this thread.
You said you finished but you didn't give me any explanation about the fact i described above.
Before you was sure about your explanation and now you don't give me any!
Yes.. My English isn't perfect, sorry.
How you explain that just 13mcg t4 in this scenario made me so worse until now after 6 day from stopping it and reintroducing the 6.25 mcg t3 i cutted?
Feel free to don't respond.
But you didn't give me any really useful information about... 😅
I am very happy to read these Papers! Where can i find them.?
healthunlocked.com/user/dio...
web.archive.org/web/2010103...
I did have a lot of articles about rT3, but I've been searching for them and can't find them. Sorry.
On Sanofi cynomel many years No problems with sanofi cynomel , 62.50 mcg. Suppressed TSH of 0.01 ft3 of 5.6 top of ref range is 6.5 so I'm good. On T3 only. I've had phizer cytomel personally don't like it but took it a few years. I've tried many others this is good quality and does the job.
I have been on Thybon - I would like to try Cynomel from Sanofi instead
Ironically, both products are from Sanofi. With Thybon Henning being German and Sanofi Cynomela being French. But they are different formulations.
Thanks for the info, yes I was thinking they are both from Sanofi, but you are right the fillers of the pills are different- and that could make the difference. I will try the Cynomel from Sanofi
It seems that people here are on a T3-only regime, what I have learned from Dr. Ray Peat it is important to have a little T4 with the T3 too. Also, it is super important to divide your T3 dosage into smaller dosages throughout the day.
BiochemNordic 'It seems that people here are on a T3-only regime'
No, only a small percentage of people here are on T3 only.
'it is important to have a little T4 with the T3 too'
What we know from the very many members posting on this forum over the years, is that a small percentage of people absolutely cannot tolerate ANY T4.
'super important to divide your T3 dosage into smaller dosages throughout the day.'
It seems Ray Peat is being far too prescriptive, a failing with doctors that we come across all the time on this forum.
There is no 'one size fits all' regime when it comes to thyroid hormone supplementation. Each individual has to find by trial and error, the dosing regime that works best for them.
Hidden You would learn an awful lot more about the thyroid and it's treatment by reading posts from fellow patients on this forum than following the out of date, questionable ramblings of Ray Peat. And for latest up to date research, be sure to follow the postings by our resident thyroid guru, diogenes (Dr John Midgley) healthunlocked.com/user/dio...
problems with T3 levels, cynomel and NHS bad batches.
Cynomel t3
Sanofi-Aventis branded T3 supplies - have they stopped selling it?
Grossman Cynomel T3
