As I posted earlier, I took 7.25 mcg this morning. I was taking 5mcg since July 12. How long before I see a change? Thanks!

[Coachgeorge]

T3 absorption

[greygoose]

That is a very, very personal thing. If I increased my dose by 1.25 mcg, I would never feel any change. In the past, I've increased by 25 mcg and not felt anything. But, we're all different. So, it's really an impossible question to answer, I'm afraid.

[Coachgeorge in reply to greygoose]

I’m feeling a little different, not better not worse. Just wondering if my mind is playing tricks on me. 🤦‍♀️

[greygoose in reply to Coachgeorge]

You could be over-thinking it.

[Coachgeorge in reply to greygoose]

I’m sure. It’s been my pattern for awhile.

[Aurealis]

I might feel it straight away or if not within a day or two

[Coachgeorge in reply to Aurealis]

Does it build in the bloodstream? I’ve felt a little better this morning but am starting to get more shaky and weak as the day goes on.

[Aurealis in reply to Coachgeorge]

Well it’s short acting but will build up a bit - in me the build up has the effect of evening out how I feel, removes the dips. You may need to eat more regularly until you get used to it, may be your blood sugar is dipping a little. You’ll soon get used to the increase. ood luck

[Hidden in reply to Coachgeorge]

It does build up after some weeks in blood, but more importantly t3 will act on cells continuously and you cannot measure its cellular activity (sometimes how I feel doesn't correlate with my results so how I feel trumps results and my doc thinks the same). So to kill this myth once for all - no, t3 is not short acting - it is only short-acting in blood, if you feel shaky after some hours is just because the dose is still off and/or you need to give it more time. Also all these graphs showing t3 peaking after 2-4 hours - yes, correct, in blood - what's the most important? Cellular activity. And that takes days , weeks etc . Hope this is clear

[Coachgeorge in reply to Hidden]

Thank you. I’ve done better today than I expected. I’m starting to get shaky but doing my best to stay out of bed. Tomorrow is another day.

[Hidden in reply to Coachgeorge]

Yes, that's excellent, celebrate these little wins! You are on the right track. I had to fight with my mind today a little. I almost asked my brain if he is for real making this even more difficult I just have to laugh, since first I had to cry for a bit this morning. Take care!

[greygoose in reply to Coachgeorge]

T3 has a half-life of 24 hours in the blood. That means that as you've taken 7.25 mcg this morning, at the same time tomorrow morning, there will be 3.625 mcg left in the blood, minus what has got into the cells. And, on Thursday morning there will be 1.81 mcg etc. etc. etc. But, it doesn't do anything in the blood. It has to get into the cells to have any effect.

The T3 that gets into the cells stays there for about 3 days. So, as you'll be taking it every day, it will build up in the cells to a certain point, and then be kept at that level by your daily dose, until you have you next increase. This is why we need to stick to the same dose every day and not alternate as we can with levo.

But, it takes a while to get into the cells. It's not instantaneous. As I understand it, it has to hang around the receptors for a while before attaching to them. How long, is probably very individual. But, you're not going to feel the extra effects of your new dose immediately after swallowing it.

[Coachgeorge in reply to greygoose]

Thank you. I did feel better today. Maybe, it’s all in my head.

[greygoose in reply to Coachgeorge]

Some of it, maybe, but probably not all of it.

[K1V1 in reply to greygoose]

Hello

Would you know what factors effect t3 not attaching to cells.

I have been on t3 only for the past 5 years With starting dose of 6.25 mcg.

I have tried several times to increase the dose but my body will not accept. And instead of more energy it shuts down even optimum level.

I am now on 12.5 mcg dose and trying to increase to 18.75mcg in split dose during the day. It seems to be working but not every day.

Any advise will be much appreciated. God bless you and all on The forum.

Thanks

Kadir Vankalwala

[greygoose in reply to K1V1]

I don't know a lot about it, but I do think that your dose is too low for you to think you have problems with absorption at a cellular level. If one has high levels of T3 in the blood but still has hypo symptoms, then one would suspect it's not getting into the cells. But, on only 12.5 mcg you're hardly likely to have high levels of FT3. Having difficulty increasing the dose is not the same problem as having an absorption problem at a cellular level. That could be due to low nutrients. Have you had your vit D, vit B12, folate and ferritin tested?

But, one thing that could stop absorption at cellular level is consuming unfermented soy in any form - soy flour, soy protein, soy milk, etc. Or, it could be a genetic problem.