We have seen many posts - and responses - regarding iodinated contrast media (ICM) and their effects on the subjects. This interesting abstract takes the view from what happens afterwards.
I can't see an obvious reason that the testing approach wouldn't also apply to the subject given ICM. Thereby helping to explain why some people react so badly to ICM.
What can be done about this? Well, apart from minimising usage (use the smallest doses possible and use only when needed), the next step might be to collect the waste from subjects. Possibly encouraging them to stay for a day or two in order that the majority of the compounds can be collected and appropriately treated.
ICM = iodinated contrast media
EDCs = endocrine disrupting chemicals
Sci Total Environ. 2019 Jul 11;692:32-36. doi: 10.1016/j.scitotenv.2019.07.159. [Epub ahead of print]
Binding of iodinated contrast media (ICM) and their transformation products with hormone receptors: Are ICM the new EDCs?
Singh RR1, Rajnarayanan R2, Aga DS3.
Author information
1 Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, United States.
2 Department of Basic Sciences, New York Institute of Technology, Jonesboro, AR 72467, United States.
3 Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, United States. Electronic address: dianaaga@buffalo.edu.
Abstract
Iodinated contrast media (ICM) have been detected at high concentrations (as high as about 3 μg/L) in surface water systems, and recently in fish brains and gonad. The mismatch between the polarity of ICM and the high lipid content of brain raises questions on whether their bioaccumulation is receptor-mediated. Furthermore, the structural similarity of ICM to the natural thyroid hormones thyroxine and triiodothyronine suggest potential binding of ICM to nuclear receptors in the endocrine system. Therefore, an in silico approach based on Surflex-Dock module of SYBYL was used to investigate the molecular docking of selected ICM (diatrizoic acid, iohexol, iopamidol, and iopromide). These ICM showed interaction with nuclear receptors that play key roles in endocrine regulation, including the androgen and estrogen receptors. Furthermore, the results indicate peroxisome proliferator-activated receptor gamma (PPARg) as one of the viable targets in the endocrine disrupting potential of ICM with higher Cscores for the ICM and iopromide transformation products than the reference ligand for the receptor. The data obtained from in silico calculations showed stronger binding of iohexol to the transthyretin-binding pocket compared to the natural hormones, thyroxine and triiodothyronine, suggesting the potential of ICM to act as endocrine disrupting chemicals (EDCs) in the environment.
Copyright © 2019. Published by Elsevier B.V.
KEYWORDS:
Bioaccumulation; Endocrine disrupting compounds; In silico approach; Iodinated contrast media; Nuclear receptor
PMID: 31336298
DOI: 10.1016/j.scitotenv.2019.07.159