Yet another paper that associates thyroid issues with the heart. It isn't that long ago that 'white coat hypertension' was coined! And here we are with a possible contributory factor.
J Clin Hypertens (Greenwich). 2019 Apr 11. doi: 10.1111/jch.13536. [Epub ahead of print]
Association of thyroid function with white coat hypertension and sustained hypertension.
Cai P1, Peng Y1, Chen Y1, Li L1, Chu W1, Wang Y2, Wang X1.
Author information
1 Department of Cardiology, Institute of Field Surgery, Daping Hospital, Army Military Medical University, Chongqing, China.
2 Key Laboratory of Basic Pharmacology of Ministry of Education Joint International Research Laboratory of Ministry Education, Zunyi Medical University, Zunyi, China.
Abstract
This study aimed to explore the relationship of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) levels with hypertension subtypes. 1056 euthyroid adults were included as research samples. They underwent measurement of clinic blood pressure and 24-hours ambulatory blood pressure monitoring. Then, they were divided into normotension (NT), white coat hypertension (WCH), masked hypertension (MHT), and sustained hypertension (SHT) groups. The 24-hours dynamic electrocardiogram was performed to analyze the heart rate variability (HRV), so as to reflect the cardiac autonomic function. The relationship between hypertension subtypes, thyroid function, and HRV was analyzed. The TSH concentration was significantly higher in the SHT group than in the NT group (P = 0.001). The FT3 concentration was higher in the SHT group than in the NT and MHT groups (P = 0.013, P = 0.008), while the FT4 concentration was significantly higher in the WCH group than in the NT group (P = 0.002). The changes in HRV were observed between the SHT, WCH, and MHT groups and the NT groups, as well as between the SHT and the MHT groups. The multiple linear regression analysis also showed that FT3, HRV (RMSSD and PNN50), and blood pressure levels linearly correlated with one another (P < 0.05). Meanwhile, the linear regression analysis showed a linear negative correlation between FT4 and HRV (SDANN) in the WCH + NT group (P = 0.001). Thyroid function was closely related to hypertension subtypes such as WCH probably due to the changes in the cardiac autonomic function.
©2019 Wiley Periodicals, Inc.
KEYWORDS:
masked hypertension; sustained hypertension; thyroid function; thyroid-stimulating hormone; white coat hypertension
PMID: 30973206
DOI: 10.1111/jch.13536
ncbi.nlm.nih.gov/pubmed/309...
White coat hypertension occurs when the blood pressure readings at your doctor's office are higher than they are in other settings, such as your home. It's called white coat hypertension because the health care professionals who measure your blood pressure sometimes wear white coats.