Is there anything that thyroid hormones don't affect, modulate, or whatever?
Intern Emerg Med. 2019 Mar 13. doi: 10.1007/s11739-019-02065-9. [Epub ahead of print]
Thyroid hormones modulate uric acid metabolism in patients with recent onset subclinical hypothyroidism by improving insulin sensitivity.
Desideri G1, Bocale R2, D'Amore AM2, Carnassale G2, Necozione S3, Barini A4, Barini A4, Lombardi CP2.
Author information
1 Department of Life, Health and Environmental Sciences, University of L'Aquila, Viale S. Salvatore, Delta 6 Medicina, Coppito, 67100, L'Aquila, Italy. giovambattista.desideri@univaq.it.
2 Division of Endocrine and Metabolic Surgery, Department of Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
3 Department of Life, Health and Environmental Sciences, University of L'Aquila, Viale S. Salvatore, Delta 6 Medicina, Coppito, 67100, L'Aquila, Italy.
4 Institute of Biochemistry and Clinical Biochemistry, Department of Laboratory Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Abstract
Some evidence suggests a relationship between thyroid dysfunction and uric acid (UA) metabolism, but the potential influential role of thyroid hormones on UA metabolism is still debated. This report was designed to evaluate the influential role of levothyroxine (L-T4) replacement therapy on circulating levels of UA in patients with recent onset post-thyroidectomy subclinical hypothyroidism. Circulating levels of thyroid hormones, UA and other metabolic parameters were assessed in 155 recently thyroidectomized patients (131 females, mean age 51.1 ± 12.7 years) at baseline (5-7 day after surgery) and after 2 months under replacement therapy with L-T4. At baseline, circulating levels of thyroid hormones were indicative of a subclinical hypothyroidism (TSH 8.2 ± 5.1 mU/mL, FT3 2.1 ± 0.7 pg/mL, FT4 9.2 ± 3.4 pg/mL). The mean serum UA concentration was 5.0 ± 1.3 mg/dL, while the prevalence of hyperuricemia, defined by serum UA levels > 6 mg/dL, was 22.6%. Serum UA levels at baseline were significantly correlated with HOMA-IR index (r = 0.475, p < 0.0001). After 2 months under the replacement therapy with L-T4, both serum UA levels (- 1.2 ± 0.9 mg/dL, p < 0.0001 vs. baseline) and HOMA-IR (- 0.3 ± 1.5 mmol/L, p = 0.0328 vs. baseline) significantly decreased. Multivariate regression analysis revealed that changes in HOMA-IR explained 23% of the variations of serum UA levels under L-T4 replacement therapy (β = 0.295, p < 0.0001, R2 = 0.230). Our study suggests that thyroid hormones could modulate UA metabolism in patients with recent onset subclinical hypothyroidism likely by improving insulin sensitivity.
KEYWORDS:
Hypothyroidism; Insulin; Levothyroxine; Uric acid
PMID: 30868444
DOI: 10.1007/s11739-019-02065-9
ncbi.nlm.nih.gov/pubmed/308...
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