Gene results : FKBP5. Double red PDEBB TSH... - Thyroid UK

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Gene results

Gcart profile image
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FKBP5. Double red

PDEBB TSH signalling double red

COMT i activationof stress hormones and oestrogen. Double red

TSHR. Double red

TRHR. Double red

The res are green !

I have some idea of what’s happening.

I thank you for any more explanations you may have .

🙂🙂

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Gcart
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I am following Gcart as interested as to what people are going to say about this. I have tried googling some of the results with no joy. I thought that when genetic tests were taken you were supposed to be offered counselling and I presumed that meant being able to discuss results with someone knowledgeable.

SlowDragon profile image
SlowDragonAdministrator in reply to

When you do just DIO2 test via Regenerus that is a "recognised " medical test and has to include counselling.

thyroiduk.org.uk/tuk/testin...

This test is sold as educational or self interest, not as a "medical DNA test". No counselling ......but it's still interesting

Gcart profile image
Gcart in reply toSlowDragon

Unknowingly I bought the battery of tests as shown

But thanks for input

SlowDragon profile image
SlowDragonAdministrator in reply toGcart

I think it's very interesting and am considering doing it myself. Just waiting for it to be on offer again

I already know I am Heterozygous DIO2, but suspect some other DNA variations might show up too

Gcart profile image
Gcart in reply toSlowDragon

I wrote a long relpy and lost it somewhere 😡 One double red shows TSH not reflecting my thyroid levels. How many others have this and are left to suffer as I was . Also one of them shows leaning toward graves . I didnt sleep more than a couple of hours for months/years . Lost a lot of weight . Only ever tested TSH !

I know I have a pituitary adenoma , no joined up thinking by medics!

All seems to point to this on the gene test.

Anyway have some quality of life now after TT and advice from this forum .

Big thankyou x

SlowDragon profile image
SlowDragonAdministrator in reply toGcart

I think it underlines exactly why one Treatment doesn't fit all patients

I have most of those as well. The ones I have:

PDEBB TSH signalling - your thyroid is "deaf" to TSH

TSHR (you are more likely to get Graves or possibly Hashis) Deaf to TSH again

TRHR Means your TSH won't correspond to your thyroid hormones. Your hypothalamus doesn't notice when thyroid hormones have gone up or down or doesn't tell pituitary what to do correctly

COMT is to do with cortisol and is often related to poor methylation, but mine is fine (although I have low cortisol), I think AA is high dopamine and GG is low dopamine

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