TSH: I was just looking at a recent post about... - Thyroid UK

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TSH

Ginny52
Ginny52

I was just looking at a recent post about the relevance of suppressed tsh, especially if this is the only way you can achieve an acceptable level of circulating thyroxine (eg in central hypo), and I wondered if it’s possible to synthesise tsh. Does anyone know?

Best to all

14 Replies
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Sorry, I have no idea. I tried looking it up, but couldn't find anything about it being synthesised anywhere except in the body.

I'm not sure if giving TSH to someone who has it suppressed would help, or if it's ever been tried.

Does anyone know?

Ginny52
Ginny52
in reply to Jnetti

I found an experiment from the 50s where they gave people synthetic thyroid releasing hormone.

Jnetti
Jnetti
in reply to Ginny52

TSH (thyroid stimulating hormone) is produced by the pituitary gland, TRH (thyroid releasing hormone) is produced by the hypothalamus of the brain. TRH acts on the pituitary which responds by producing TSH, which acts on the thyroid gland to produce more hormone.

I looked for "Synthetic TRH" and it is used medically or in research, but the only articles found so far are too technical for me at the moment.

I think it would only help if the problem was in the hypothalamus (congenital or through injury?)

Ginny52
Ginny52
in reply to Jnetti

Yes-the findingof the experiment was that if the pituitary was intact, pituitary hormones rose, but if it was compromised, they didn’t, so it was being proposed as a way to distinguish between secondary and tertiary deficiencies. I suppose it never went anywhere because the wonderful Tsh test came along xx

Jnetti
Jnetti
in reply to Ginny52

interesting!

Ginny52
Ginny52
in reply to Jnetti

And now the tsh gold standard misses everything except primary hypothyroidism

Jnetti
Jnetti
in reply to Ginny52

Do you have a link to the experiment? Sounds interesting!

Ginny52
Ginny52
in reply to Jnetti

I’ll try to find it again x

Ginny52
Ginny52
in reply to Jnetti

If you google Synthetic Thyrotropin Releasing Hormone- A Potent Stimulator

It’ll come up faster than my linking powers will send it.

From 1971 so made irrelevant by the Tsh hegemony

Jnetti
Jnetti
in reply to Ginny52

Thanks, will have a look when I can x

Jnetti
Jnetti
in reply to Ginny52
Ginny52
Ginny52
in reply to Jnetti

I don’t know if this is how Trh is used now to test for Tsh deficiency. I am rather hoping to find out in the not too distant future! X

Jnetti
Jnetti
in reply to Ginny52

I found something that was reviewed in 2018. It seems that TRH has more than one use

drugs.com/pro/thyrotropin-r...

Ginny52
Ginny52
in reply to Jnetti

Excellent!

I read lots of papers that say central hypo is vanishingly rare, but they seem to have next to no interest in diagnosing it, so the rarity comes as no great surprise.

‘Central hypothyroidism is often missed’- well, it will be if you don’t look for it. So blasé about leaving people to the joys of untreated thyroid deficiency! XG

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