Synthetic to NDT: Currently taking 100 mcgs of... - Thyroid UK

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Synthetic to NDT

Suzy61Taylor profile image

Currently taking 100 mcgs of levothyroxine and 20 mcgs of Liothyronine. What would be an equivalent dose of NDT. I’m mostly well with private bloods showing reasonable results. My main concerns are the headaches. I get them 1 - 2 hours after taking my meds. It happens daily so it’s not coincidental. Also, should I transition slowly and take a combination of both synthetic and NDT (but not exceeding my daily dose), or just swop over to NDT. Daily headaches are miserable and I can’t ignore them anymore. I haven’t posted for a while now but I like to read other questions. An amazing supportive forum. Many thanks.

6 Replies
shaws profile image

1 grain of NDT is stated to be around 100mcg of levothyroxine. 20mcg of lio is around 60mcg of levo. We can do a straight swop from one to another without problems.

If you prefer you can start with a slightly lower dose.

Take note of pulse/temp and if either rises, reduce dose slightly. Taking account of your clinical symptoms you can also add a small amount every 2 weeks. The aim is relief of syptoms.

Suzy61Taylor profile image
Suzy61Taylor in reply to shaws

Thank you Shaws :)

Thiroyd is said to contain 35 mcg T4 and 8.31 mcg T3 per grain; other brands contain 38 mcg T4 and 9 mcg T3.

So, for near equivalents to your current dose, 3 grains of Thiroyd would supply 105 mcg T4 and 24.93 mcg T3, while 2.5 grains of other brands would supply 95 mcg T4 and 22.5 mcg T3. You may prefer to start on 2.5 grains of Thiroyd or 2 grains of other brands, plus 25 mcg of levothyroxine every day or two.

Thank you for taking the time to reply

Hi Suzy, are you taking your meds all in one go? If so then I wonder if spacing your dose into 2-3 smaller doses each day might alleviate the headache. I used to take a combo of T4 and T3 like you, and found multi-dosing helped, as did fully recovering - hardly ever get a headache now. Now I’m on NDT and T3, which I take in three doses at 5:30am, 11:30am and 4:30pm. A bit of a pain at first, but I’m used to it now, and it works for me. Maybe just try splitting it into a morning and afternoon dose. All the best with it, I hope you feel better soon.

That’s very helpful. Thank you Blue Bee :)

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