Does talking Aldactone effets T4 blood test ?

[Mariem33]

I’m taking Aldactone for about one week (for PCOS ) I wanna check my T4 and TSH level .

[shaws Administrator]

I am not sure if it affects levothyroxine blood test. You state that you take Aldactone for PCOS. Do you have any of the following symptoms and is this why GP prescribed (I am not medically qualified) ?

Aldactone removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease. It also can be used in combination with other drugs to treat elevated blood pressure, and for treating diuretic-induced low potassium (hypokalemia).

[MaisieGray]

Good question. There's a small piece of research - from 1979 so you may want to look for other/newer references to validate it - that found that four weeks high dose spironolactone treatment (Aldactone, 100 mg q. i. d.) significantly enhanced the TSH and T3 responses in 6 eumenorrhoeic euthyroid hypertensive women, without affecting basal serum TSH, T3 or T4 levels. The conclusion was that Spironolactone (Aldactone) may, possibly by virtue of its antiandrogenic action, exert its enhancing effect on pituitary-thyroid function by modulating the levels of receptors for TRH in the thyrotrophs or by altering the T3 receptor in the pituitary permitting a greater response to TRH.

[Mariem33 in reply to MaisieGray]

Thank you