Hello all. I have been on a t3/t4 regime for 3 months now. Doses are 125mcgs (t4) & 25 mcgs (t3). I'm a 30 yr old male, very active physically and weigh around 200lbs with a muscular frame.
This is a long post about a situation that isn't common. If you want a quick summary of this post, please go to the end of the post.
I have Hashimoto and before going on my current thyroid regime, my lab work was "fine" except for high antibodies. In these three months of my thyroid regime, I've had 3 (yep, THREE) superficial vein thrombosis (blood clots), although I suspect one was a deep one (DVT). Scary stuff.
My TSH is undetectable with my current thyroid regime; it's 0.005 (lowest I've read in this forum).
T4 is middle of the range.
T3 was middle of the range one month after starting this regime (surprised by this; thought it'd be higher). Last lab work two months later (i.e. 4 weeks ago) didn't test T3 (silly health care system).
The goal with this thyroid regime is to suppress TSH so antibodies go down. Indeed, they've gone down and down. Good stuff. I feel absolutely fine.
THE PROBLEM: (?)
I have Factor V Leiden (hetero), which means that I am slightly more prone to clotting than people without this. I've been doing a lot of research and there's some suspicion that a "hyperthyroid" state may increasing blood clotting. The research is muddy as there isn't much and there's some that points to a hyperthyroid state leading to hemophilia (increased bleeding) and NOT thrombophilia.
I was diagnosed Hashimoto over a decade ago and I've been on a couple of long-term thyroid regimes similar to my current one.
I have had two DVTs in the past and both were when I was on my thyroid regime with similar lab work (including undetectable TSH). Before starting my current thyroid regime three months ago, I was 6 years off any thyroid medication and I didn't have any clots whatsoever. But, as soon as I started my thyroid regime three months ago, I started having clots.
What scares me is the extremely low TSH, which could be causing hyper coagulability (just a thought). Yet my t3 was in range when tested as so was t4.
1) Go off the thyroid medication and continue to watch my Hashimoto. My last lab work detected an extremely low level of vitamin D (15.2 ng/ml, when range is 20nm/ml and above). I'm currently treating this deficiency to get my levels top of the range. Vitamin D deficiency is associated with auto-immune disease, so the idea is to go off the thyroid medication, continue with high-dose vitamin D to get levels up and watch antibodies.
How would I go off my current thyroid regime? I'm very active physically, so really need my thyroid to bounce back smoothly.
2) The second option is to alter the dose (i.e. lower t3), but I may still get more clots as I find a threshold dose. This would involve more lab work and the hope of not developing more clots until I find such threshold.
I'm currently on low-dose heparin for my last clot. I'll be off it in a couple of weeks, so I have to decide what to do.
Stop my thyroid meds and continue with high-dose vitamin D while keeping a watchful eye via further lab work?
Or try to find a threshold dose?
Many thanks for any help offered.
- I'm a 30 yr old male on 25mcgs (t3) & 125 mcgs (t4) since 3 months ago. Lab work is fine except TSH is 0.005 (extremely low).
- I have Factor V Leiden and I've had 3 blood clots since starting thyroid regime (last 3 months).
- I have had 2 major blood clots in the past when I was on a similar thyroid regime. I've been on and off thyroid meds and never had a clot when OFF thyroid meds.
- Suspicion is that current thyroid regime may be putting me in a hyper-coagulating state. There's research hinting that pharmaceutically-induced "hyperthyroidism" may lead to increased clotting.
- Options are to go OFF thyroid meds OR to try to find a threshold dose that keeps lab work in check and which also doesn't cause clots.