Paper showing effects on cholesterol in T4 therapy by the Bianco group.

[diogenes]

Helvella wrote about this yesterday and produced a summary because the full paper is paywall protected. I've deposited the full paper with Louise Roberts at TUK for those interested. It shows that cholesterol levels of whatever form are not normalised by levels of T4 therapy giving normal range TSH. This mirrors the earlier work of Ito showing that other markers like sex hormone binding globulin are also not normalised, and require TSH down to 0.03-0.5 to be so. The "euthyroid" state therefore needs lowered TSH on therapy, almost down to undetectable. Some will need undetectable TSH to achieve "normality". Just as we've shown ourselves, and the reasons why this is so.

[helvella Administrator Thyroid UK]

the reasons why this is so are what Bianco, et al., manage to miss/ignore.

[helvella Administrator Thyroid UK in reply to helvella]

My original post is available here:

healthunlocked.com/thyroidu...

[shaws Administrator]

Thank you for posting Diogenes. Quality is always better than quantity. So rather than giving patients statins, they should increase dose of T4 to bring TSH to 0.03-0.5 .