Prolonged Duration of Hashitoxicosis in a Patient with Hashimoto’s Thyroiditis: A Case Report and Review of Literature

[helvella]

Distinguishing between Graves and Hashimoto's is important but we do see quite a few questionable diagnoses here. Important to note the mildly elevated TSI in this case.

Good to see a case handled with subtlety and, apparently, sympathy.

Cureus. 2018 Jun; 10(6): e2804.

Published online 2018 Jun 14. doi: 10.7759/cureus.2804

PMCID: PMC6093271

Prolonged Duration of Hashitoxicosis in a Patient with Hashimoto’s Thyroiditis: A Case Report and Review of Literature

Monitoring Editor: Alexander Muacevic and John R Adler

Amir Shahbaz,

Abstract

Hashitoxicosis is the initial hyperthyroid phase of patients with Hashimoto's thyroiditis and, usually, this phase lasts for one to two months. We report a case of a 21-year-old male who had Hashitoxicosis of two years duration before converting to Hashimoto’s hypothyroidism. He initially presented with complaints of increased appetite, heat intolerance, fatigue, and sweating. On a physical exam, he had mild exophthalmos with lid lag and a fine tremor in the hands. Thyroid function tests also confirmed that the patient had hyperthyroidism. Thyroglobulin antibody and thyroid peroxidase antibody were both positive. He also had mildly elevated thyroid-stimulating immunoglobulin (TSI) but decreased radioactive iodine uptake scan. Based on the clinical presentation and biochemical test, a diagnosis of Hashitoxicosis was made. This hyperthyroid phase lasted for a period of two years. The patient eventually developed hypothyroidism suggesting that Hashimoto's thyroiditis was the most likely diagnosis. He was started on levothyroxine replacement therapy and remained euthyroid on levothyroxine since that day. The initial presentation mimicked Grave’s disease, but with decreased radioiodine uptake, despite the high TSI level, leading us to treat him medically and not with radioactive iodine therapy. The patient was thus spared unnecessary radioactive iodine therapy (RAI) therapy.

Keywords: hashimoto's thyroiditis, hashitoxicosis, grave's disease

Full paper freely available here:

ncbi.nlm.nih.gov/pmc/articl...

[Hidden]

Thanks for the reference, it was just what I was after

[helvella Administrator Thyroid UK in reply to Hidden]

Your lucky day.

[Hidden in reply to helvella]

👍

[humanbean]

Wow, that is a breath of fresh air - doctors getting it right, understanding what they are dealing with, and having some compassion for the patient. Amazing!

[Salsybar73]

my son who is 19 eats a lot , gets tremors in hes hands and was diagnosed with hypothyroidism 8 weeks ago. he does not put weight on , he had hes tpo and tga done both came back good, hes t3 was 5.1 hes tsh was 4 and hes t4 was 15 .