Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case-Control Study

[helvella]

I know nothing about oral lichen planus - but have seen several mentions here so hope this paper might be of some interest.

Front Endocrinol (Lausanne). 2018 Jun 18;9:330. doi: 10.3389/fendo.2018.00330. eCollection 2018.

Correlation Between Oral Lichen Planus and Thyroid Disease in China: A Case-Control Study.

Zhou T1, Li D1, Chen Q2, Hua H1, Li C1.

Author information

Abstract

Background:

A possible relationship between oral lichen planus (OLP) and thyroid disease has received attention in recent years.

Objective:

This study aimed to evaluate the correlation between OLP and thyroid diseases in Chinese ethnic patients.

Methods:

192 OLP patients, 123 patients with oral lichenoid lesions (OLLs), and 162 controls were recruited in this case-control study. All participants received screening for thyroid function and underwent ultrasound. Sex and age of the patients in the three groups were matched. The prevalence of thyroid diseases in the subjects was analyzed. Using logistic regression, the odds ratio (OR) with 95% confidence intervals was appraised for associations between OLP, OLL, and different types of thyroid diseases [Hashimoto's thyroiditis (HT), hypothyroidism, and thyroid nodule].

Results:

The prevalence of thyroid diseases in the OLP group (72.4%) and OLL group (68.3%) was higher than the control group (49.4%) with statistical significance. The OR of HT was 3.16 (1.87-5.33) for OLP, 2.09 (1.18-3.70) for OLL, while the OR of thyroid nodule was 2.31 (1.30-4.09) for OLP.

Conclusion:

Our study suggested a close relationship between OLP/OLL and HT and thyroid nodule in a Chinese population. The possible mechanism behind this association warrants further investigation.

KEYWORDS:

Hashimoto’s thyroiditis; hypothyroidism; molecular mimicry; oral lichen planus; oral lichenoid lesion; thyroid nodule

PMID: 29967591

PMCID: PMC6015892

DOI: 10.3389/fendo.2018.00330

ncbi.nlm.nih.gov/pubmed/299...

Full paper freely available here:

ncbi.nlm.nih.gov/pmc/articl...

[stiltzski]

Interesting...I wonder if there is also a correlation between lichen sclerosus and thyroid disease.

[revkrow in reply to stiltzski]

I wonder that too. I have hasimotos, exzema and lichen sclerosis - I suspect they are all related. Any advice fro anyone?

[CS1964 in reply to stiltzski]

Oh my goodness, I also have lichen sclerosis, Hypothyroidism, Coeliacs , carpal tunnel and peripheral neuropathy..... these are all autoimmune conditions....I am desperate for healing lichen sclerosis as I have had it for 14 years, I was diagnosed only last year for the rest of my conditions

[stiltzski in reply to CS1964]

I feel there must be a link. I also have carpal tunnel syndrome, hypothyroidism, fibromyalgia as well as Lichen Sclerosus. I am also in constant pain from what I think is piriformis syndrome but my GP isn’t interested. I had glandular fever as a teenager which I also think is linked.

[CS1964 in reply to stiltzski]

I wonder too