We've got published our editorial summarising the several papers we wrote in Frontiers in Thyroid Endocrinology on the workings of the thyroid and its relationship to body T4-T3 conversion. It's still not completed in that the references aren't published, but the text is for anyone interested. It's a bit dry and couched very scientifically but if anyone's interested its in open form at:
Deeper insights in the physiology of thyroid function and its homeostatic control warrant a rethinking of diagnostic practice. The old paradigm employing TSH in the centre of diagnostic work-up has to be replaced by a relational concept, where TSH is interlocked with FT4 and FT3, and multivariable distributions represent homeostatic equilibria.
Insofar as I can understand, that makes much sense. However, there I do have a question:
How does this get implemented by GPs in real-world surgeries?
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