Tsh suppression

[Greybeard]

I came across this recent research paper.

journals.plos.org/plosone/a...

One of its claims is that tsh suppression is controlled 52% by t4, 38% by t3 and the other 10% by a combination of the two hormones.

Is there any evidence of this in practice? Do those on t3 have less suppressed tsh than those on t4, ndt or a combo of t4 and t3?

[helvella Administrator Thyroid UK]

I suggest you look at the Thyroid UK advisors here:

thyroiduk.org.uk/tuk/About_...

And at the authors of the paper you have just linked to.

thyroiduk.org.uk/tuk/About_...

Our member here, diogenes , is in fact:

Dr John Midgley B.Sc (Leeds) D Phil (Oxford)

University Lecturer, Biochemistry/Molecular Biology; Leeds and Newcastle-upon-Tyne Universities 1962-1975: Clinical Trials Coordinator, Diagnostic Products, Amersham 1975-1988: Inventor, one-step methodologies for FT3/FT4 measurement 1980 and 1988: Winner, Prince of Wales Award for Industrial Innovation and Production 1985: Consultant, Diagnostic Methodologies 1988-1998: Trials Abstractor, Gastroenterology, Cochrane Collaboration, 1999-2006. Independent writer and reviewer, thyroid function test interpretation 2001-date: Author of 70 + papers and reviews on bacterial molecular biology/ clinical thyroid function diagnostics.

[jimh111]

This is a complicated paper that looks at what happens in real life subjects. If you want to know what happens when you take T3 or T4 this paper ncbi.nlm.nih.gov/pmc/articl... shows that liothyroine tablets are about three times as potent as levothyroxine. i.e. 10 mcg liothyroine will have the same effect on TSH as 30 mcg levothyroxine.

[Greybeard in reply to jimh111]

Thank you I will read and try to absorb.