Here's something I copied and saved, that somebody else posted a link to on here, but I seem to have missed off the end, sorry:
What about Thyroid Hormone Resistance - and I very much doubt anyone in the UK is aware of such a diagnosis. This is a small excerpt as I do know you have disabling symptoms, it would appear. Excerpt:
Dr. Lowe: If a patient has either "general" or "pituitary" resistance to thyroid hormone, this is indicated by the results of thyroid function tests. However, our studies suggest that perhaps 40% of fibromyalgia patients have "peripheral" tissue resistance to thyroid hormone—not pituitary or general resistance.
Patients who have peripheral tissue resistance to thyroid hormone have normal thyroid test results before treatment with thyroid hormone. So, we don't know that they have peripheral resistance until we've treated them with plain T3. (Of course, we treat them with T3 as part of more comprehensive metabolic rehabilitation). A three-part therapeutic outcome tells us which patients have peripheral resistance.
First, resistant patients recover from their hypothyroid-like symptoms and signs only with extraordinarily large dosages of T3 (called "supraphysiologic" dosages). Second, despite these large dosages—which might hospitalize a person who doesn't have tissue resistance—the patients have no indication of tissue overstimulation. (We use various objective tests to rule out overstimulation, such as serial EKGs and various biochemical tests. We also closely scrutinize patients and use various physical exam procedures such as the Achilles reflex test.) Third, although the patients have recovered from their symptoms and signs with high dosages that don't overstimulate them, lab tests show that they have extremely high blood levels of free T3.
Two excerpts from another link by Dr L:
"The fact is, however, TSH and thyroid hormone levels are highly unreliable indicants of whose body is under-regulated by thyroid hormone. The levels are so unreliable that the testing should be abandoned as the standard method for identifying such patients."
"Many researchers have noted that fibromyalgia symptoms are virtually identical to those of hypothyroidism. Indeed, as my collaborator Jackie Yellin, has shown, the most well-documented features of fibromyalgia are exactly the same as features of hypothyroidism (see Table 1).
Studies by several research teams indicate that 90% of fibromyalgia patients have underlying thyroid diseases. Studies by researchers in the U.S., France, Germany, and Italy show that these thyroid diseases include primary and central hypothyroidism and peripheral cellular resistance to thyroid hormone. It’s important to note, however, that most patients’ fibromyalgia symptoms caused by thyroid disease are compounded by other metabolism-impeding factors. The most common factors are poor diet, nutritional deficiencies, poor physical fitness, and metabolism-impairing drugs.
When fibromyalgia patients receive effective treatment for hypothyroidism or peripheral thyroid hormone resistance, most are fully and lastingly freed from their fibromyalgia symptoms. Several open but systematic trials and several blinded studies have shown that metabolic treatment including thyroid hormone therapy completely relieves most patients’ symptoms. In another double-blind crossover study, researchers reported a positive therapeutic effect on fibromyalgia from transdermal T3. In a randomized double-blind, placebo-controlled study, clinicians used multiple therapies. In that study, as Peter Warmingham noted in an article titled "Fibromyalgia has been solved," 90% of the fibromyalgia patients used thyroid hormone and 90% improved. These are the only studies in which patients have largely or fully recovered from fibromyalgia symptoms; each involved thyroid hormone therapies other than T4-replacement, an approach documented to fail to relieve a large percentage of hypothyroid patients of their symptoms.
p.s Peter Warmingham has written about the 'Myths of TSH'.:-
Dr Skinner and Dr Peatfield paid no atte