Thyroid UK
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Triiodothyroacetic acid in health and disease

We very occasionally see some of the "other" substances in the thyroid hormone family mentioned. One such is TRIAC - and this paper is a review of what we know of it.

This is very much for those who are interested in the subject in general. Unlikely anyone will actually get any personal treatment benefit from this paper.


Triiodothyroacetic acid in health and disease

Stefan Groeneweg, Robin P Peeters, Theo J Visser and W Edward Visser⇑

S Groeneweg, Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 CN, Netherlands

R Peeters, Internal Medicine, Erasmus MC, Rotterdam, 3000DR, Netherlands

T Visser, Internal Medicine, Erasmus MC, Rotterdam, 3015 GE, Netherlands

W Visser, Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands

Correspondence: W Edward Visser, Email: w.e.visser{at}


Thyroid hormone (TH) is crucial for development and metabolism of many tissues. The physiological relevance and therapeutic potential of TH analogs have gained attention in the field for many years. In particular, the relevance and use of 3,3',5- triiodothyroacetic acid (Triac, TA3) has been explored over the last decades. Although TA3 closely resembles the bioactive hormone T3, differences in transmembrane transport and receptor isoform-specific transcriptional activation potency exist. For these reasons, the application of TA3 as a treatment for resistance to TH (RTH) syndromes, especially MCT8 deficiency, is topic of ongoing research. This review is a summary of all currently available literature about the formation, metabolism, action and therapeutic applications of TA3.

Received 24 February 2017

Received in final form 26 May 2017

Accepted 30 May 2017

Accepted Preprint first posted online on 1 June 2017


The full paper is, at time of writing, available on the site above - but it is in pre-publication format - double-spaced, every line numbered, etc. Sometimes the final paper might be available, but all too often, as soon as a final version is available, it gets put behind a paywall.

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Taking triac for fat loss as a bodybuilder is what (I think) destroyed my thyroid and adrenals. Probably OK if you never stop it. Can you stil get it OTC in France?

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