Hi just dropping by to let you all in on the reason many people are treated for an underactive thyroid gland but have little response to treatment. To start i was symptomatic 4 years before the lab values confirmed hypothyroidism. I was prescribed synthroid by a rheumatologist who diagnosed me. My gp for three years tested my tsh and said that unless my tsh was out of wack a full panel was not nessesary ... SO VERY WRONG. So finally with ANA antibodies of 1/100 he sent me to a rheumatologist who did the full panel. So synthroid i took for 22 years still symptommatic ... finally my dt decided to test the two hormones t4 and t3. My t3 was none existant. It is your active form of thyroid replacement. Your metabolism! The conclusion was made that i was missing the conversion factor. I was soon supplemented with synthetic t3 as well as a low dose of t4. My symptoms improved a bit but four years later i decided synthetic is just that man made not natural. I have been on naturethroid for 5 years and have never felt better ...even menopause is a breeze for me. So people be your own advocate for your health ... if your dr. Is not willing to do a full panel for diagnosis then how do you really know how to treat the discrepancy. Also natural replacement has t1 ans t2. Not sure what these hormones do but i am sure the bodies needs them. So basically folks this is my analagy...They flooded my car with gas (t4) but i could not burn (use) it as it was not in its active form ... i had wasted so many years that i could have felt great all because some health givers just dont get it. Conversion of t4 to t3 is very important for optimal health. Always remember you dont put desiel in a gasoline engine for a reason !