Where are anti-bodies born/produced?

Hello,

I know that the body itself produces thyroid antibodies.

But I'm really curious. Where exactly are thyroid antibodies are produced in the body?

Where are they born?

For instance, does the bone marrow -do to a malfunction- produce them?

Or are they a sort of white blood cells that went crazy and decided to become an antibody?

From where do those little things spring?

4 Replies

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  • FleureDee,

    Thyroid peroxidase and thyroglobulin belong in the thyroid gland and nowhere else. When the thyroid gland is damaged peroxidase &/or thyroglobulin spill into the blood and the body sees them as invaders and gets the immune system to send antibodies to fight them off.

    study.com/academy/lesson/wh...

    thyroiduk.org.uk/tuk/about_...

  • Hmmmm, Interesting. The idea I always had was that the body -some some reasons- starts to create antibodies that go to the thyroid gland and starts hurting it. I thought this was the case with all auto immune disorders.

    What you are saying is the other way round! The thyroid has a problem, it "leaks" some of its own secretions that should not be in the blood stream, and the body normally crates antibodies.

    I though that auto immune disorders mark a malfunction in the body's immunity system. But what you are saying means that the immunity system is perfectly doing its job. It is the organ (thyroid in this case) that went crazy and started to act abnormally.

  • FleureDee,

    No, I'm saying that the immune system went awry and thought the thyroid gland was an invader so lymphocytes* (a type of white blood cell) are sent to fight off the invader. When the lymphocytes infiltrate the thryoid gland cells are destroyed and thyroid hormone is dumped into the blood. Antibodies are a response to the autoimmune attack and thyroid peroxidase and thyroglobulin in the blood.

    *Lymphocytes google.co.uk/search?q=lymph...

  • I see. Thank you very much for the clarification.

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