Until November last year, I was on 75 mcg of T4 and after a blood test, was told to increase to 100 again. Due to never having felt well on T4 for whatever reason, I was reluctant to increase so my doctor suggested it might be worth trying T3 and I am now seeing a consultant who agreed initially to a 3 month trial. She reduced my T4 to 25 mcg and added 10 mcg of T3. Despite being a small dose, I noticed an improvement in my symptoms for a few weeks (mood in particular) then seemed to struggle again. After a blood test in January, my TSH had risen to 11.56 (0.3-5), Free T3 4 (3.1-6.8) and free T4 11.6 (12-22) so a further increase of 10 mcg was added. Again, this helped for a few weeks (much better than when on T4 alone) but then started to feel tired and unable to think clearly again. I explained this to the consultant at my appointment a few weeks ago so she agreed to stopping the T4 altogether (which we had discussed previously) and adding a further 10 mcg T3 therefore now taking 3 x 10 mcg T3 a day and have been told to have a blood test done before my next appointment in 3 months. I started to feel much better again last week and over the weekend (almost 'normal'!) then after a reasonably busy day on Monday, have felt exhausted and not right since. Can anyone advise me as to whether it is just a matter of getting the right dosage in order to feel consistently ok and also if it might be better to take the 30 mcg in a single dose? I appreciate that we are all different and will therefore require different amounts of T3 but I would also be interested to know how much of T3 alone other members are taking and if taking in a single dose or split. Apologies for the lengthy post and hope someone can advise.