Thyroid peroxidase identified in human granulosa cells: another piece to the thyroid-ovary puzzle?

The idea reported here has been suggested many times - but this is the first time I have seen what is claimed to be clear, evidence.

Don't forget folks, thyroid is simple…

Gynecol Endocrinol. 2017 Mar 5:1-3. doi: 10.1080/09513590.2017.1296424. [Epub ahead of print]

Thyroid peroxidase identified in human granulosa cells: another piece to the thyroid-ovary puzzle?

Monteleone P1, Faviana P2, Artini PG3.

Author information

1 a Department of Obstetrics and Gynecology , USL Toscana Nordovest , Lucca , Italy.

2 b Pathology Unit, Department of Surgical, Medical and Molecular Pathology and Critical Care, University of Pisa , Pisa , Italy , and.

3 c Department of Experimental and Clinical Medicine , Division of Gynecology and Obstetrics, University of Pisa , Pisa , Italy.


Thyroid hormones seemingly influence the maturation of the human oocyte. Thyroid hormone receptors have been isolated in granulosa mural and cumulus cells and the mature oocyte of the human ovarian follicle. Thyroid hormones are present in follicular fluid in concentrations similar to those in serum. Most importantly, enzymes involved in the chain that regulate the generation of thyroid hormones have been found in granulosa cells. For the first time, we have isolated thyroid peroxidase by immunocytochemistry in the granulosa cumulus cells of the human ovarian follicle, thereby supporting the hypothesis that the human ovarian follicle may be an independent thyroid-hormone producing unit.


Follicle development; granulosa cells; ovary; thyroid peroxidase

PMID: 28277109

DOI: 10.1080/09513590.2017.1296424

13 Replies

  • Wow! I never knew that.

  • Wow! So interesting! So what happens after menopause when reports say as hypo women get older they need less thyroid medication?

  • That very thought went through my brain.

    And out the other side without doing anything useful. :-)

  • 😳🤣🤣🤣

  • MissLillyskisses is there actually any scientific evidence to show post menopausal women need less thyroxine. I was alarmed to read a research article claiming older women can have TSH of well over 10 and be fully optimised 😳 I don't think so ...mine likes to be completely suppressed. It sounds like a wicked fairytale to justify leaving older women to rot because we are deemed worthless to society. There was no mention of older men needing a TSH even higher that the bonkers upper range limit here. I wish I could by magic give them a TSH of more than 10 so they could experience their supposedly adequate for old ladies medicine. what does this article imply I do not really understand what significance it might have.

  • TSH110 they were statements I've read over the years! I'm sure HRT and medications for other conditions can all have an impact on thyroid levels and we need to be the driving force to maintain/regain optimum health, whatever age, not be fobbed off and walk into GP surgeries a Queen, even if it is a facade, because if we look defeated walking in, we will certainly be fighting back the tears walking out. My very best wishes to you.

  • Hmmm, I doubt that. I suspect it's just that post-menopausal women who were not previously diagnosed as hypo have higher TSH and lower frees as their ovaries shrink: so therefore all older women need less hormone. Whether they feel well or not probably depends on the individual (as do menopause symptoms).I know that my pelvic scan showed almsot non-existent ovaries.

  • its so complicated for my brain hevella

  • helvella amala57 TSH110 Angel_of_the_North bluepettals2 I think it means that the ovaries have an independent thyroid supply away from reliance of supply from blood circulation.

    This article is very interesting in detailing IVF failure: "It is increasingly evident that thyroid autoimmunity, rather than thyroid hormone concentrations, may impair IVF cycle outcomes"

  • Logic suggests that your body could be making TPO antibodies even after a total thyroidectomy - if the ovaries do actually actually have TPO in them.

  • Absolutely helvella.

  • miss lillykiisses thanks fo r that my blood circulation is utterly cr**p anyway. I need a new body a new head and anew endocrine system and new head of hair and new skin..

  • Big hugs bluepettals2 😢

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