Toxic and Endocrine Myopathies

[helvella]

Many here are well aware of the issues surrounding statins. That they can cause myopathy has often been stated. There are many papers which mention that, but most dismiss the issue as "rare" and deny any association with thyroid disorders.

I thought it interesting that this paper mentions statins and other lipid-lowering medications. Is it the lowering of cholesterol that is at the heart of causing myopathy?

Continuum (Minneap Minn). 2016 Dec;22(6, Muscle and Neuromuscular Junction Disorders):1815-1828.

Toxic and Endocrine Myopathies.

Katzberg HD, Kassardjian CD.

Abstract

PURPOSE OF REVIEW:

This article discusses the clinical features, pathophysiology, and management of toxic and endocrine myopathies.

RECENT FINDINGS:

Early detection and expeditious correction of metabolic disturbances in endocrinopathies such as Cushing syndrome, thyroid and parathyroid diseases, and acromegaly can minimize and prevent neurologic complications including myopathy. Recently proposed mechanisms of injury in patients with critical illness myopathy include inhibition of protein synthesis, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, oxidative stress, and disruption of intramuscular calcium homeostasis, which can cause a myosin-loss myopathy. Mechanisms underlying toxic myopathies include myosin loss; damage to cellular structures, including myofibrils and organelles such as lysosomes and mitochondria; inflammation; and necrosis. Presentations range anywhere from acute, painful, and necrotic myopathies, as can occur in statin myopathy, to more insidious presentations such as steroid myopathy.

SUMMARY:

Endocrinopathies known to cause myopathy include thyroid and parathyroid diseases, disorders of the adrenal axis such as Cushing syndrome, and acromegaly. Patients in the intensive care unit are at risk for developing critical illness myopathy, also known as myosin-loss myopathy, which should be considered if intensive care unit acquired weakness develops. The most common toxic agents associated with myopathy include statins and other lipid-lowering medications, corticosteroids, colchicine, amiodarone, hydroxychloroquine, and chloroquine.

PMID:

27922495

DOI:

10.1212/CON.0000000000000407

ncbi.nlm.nih.gov/pubmed/279...

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Our bodies need cholesterol, can't make Vit D from sunshine without it. The liver makes cholesterol overnight for its needs.