wow. - its like I'm taking an entirely differnt medication, yet they are all levothyroxin; have just moved to Mercuary pharma, from a mix of workhardt and acuvist (think they've called) brands, and the differnce is amazing; no muscle cramp, pain, or weakness, no heart palpitations, no brain fog, and no fatigue, and this before the dose gets increased to nearer what it should be; currently on 50 McG a day, having secondary hypothyroiditus, from panhypopituitarism due to a TBI. - I'm next looking in to switching brand/make on the prednisolone I take for the secondary addisons, from the panhypopituitarism. just really to post this here, to highlight what an amazing differnce in my quality of life, just as a result of speaking to my pharamicist (of course the endocrine Drs and nurses at hospital were no help, and the Dr at the GP sugery just pointed me towards the pharmacist.). there is hope..