Thyroid UK
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Feeling better...but!

Hi all, I posted a few weeks ago having just been diagnosed with hypo .my doc put me straight onto 100 mcg levo thyroxine as my tsh was 11 (I think)

I felt no difference in the first week ,slightly better in the second ,and bloody marvellous in the third!(compared to pre diagnosis) I was like tigger ! Then on the Sunday ,whilst at a BBQ I put the gluten free trial aside and stuffed my face with quiche sausage rolls and god knows what .the next day I literally could not get out of bed and was late for work .why is that ,that gluten should have such a bad effect on me (I never felt this bad whilst on a gluten full diet ) does it react with the levo thyroxine ?

I have read all the gumph on gluten being similar in makeup to thyroxine but I just don't get it! I am intelligent (apart from the fogs!) but I just don't understand !

Needless to say I have resumed the gluten free diet !

I would also like advise on when to take the thyroxine .i take it usually in the morning but am having to wake up mega early to take it so that I can have breakfast before work at 8 (I leave an hour before caffeine and food) .some people take theirs at night ?



7 Replies


Gluten is not similar in makeup to thyroxine. Having eliminated gluten for 2-3 weeks and then experienced an adverse reaction when you reintroduced it indicates you have an intolerance or sensitivity to gluten.

Levothyroxine can be taken any time of day or night if you take it with water 1 hour before or 2 hours after food and drink, 2 hours away from other medication and supplements, and 4 hours away from calcium, iron, vitamin D supplements and oestrogen.


Hi ,that was the article I read , my mistake that I didn't read it properly ! Oops ! That's it then ,no more cakes for me ! Bummer!

Is the article saying that I will be suffering the effects of that lapse for 6 months !

It might seem like a stupid question but if one didn't have a thyroid ,would one still be intolerant to gluten ? (Maybe you can't answer that one !)

Thanks for the info on timings ,might change to a night time ! Will it effect energy levels etc ?



If the villii in your gut have become inflamed after eating gluten it may take up to six months for them to recover, it doesn't mean you will feel ill for 6 months. You don't have to give up cake :) There are many gluten-free cakes, biscuits and breads.

Gluten intolerance has nothing to do whether one has a thyroid or not. It is thought that gluten may trigger Hashimoto's attacks due to perceived similarities to gliadin in gluten with the thyroid gland and many Hashi patients have found symptoms improve and antibodies reduce when they go gluten-free.

Research has shown that TSH may be lower when Levothyroxine is taken at night. Energy levels will only improve when you are optimally medicated and when vitamins and minerals are optimal.


All the info I have read now makes perfect sense!! And it is such a relief to know that I won't be "ill"off a handful of sausage rolls and quiche ! The question I have now is ,that if ,as you suggest huashimotos is triggered by gluten ,then how come underactive thyroid is classed as a lifetime disease(i.e I will be on thyroxine for life)

It sounds as though there may be a chance that if I follow a gf diet ,my thyroid might function as normal eventually (what's left of it anyway!) what do you think?



Autoimmune thyroid disease (Hashimoto's) causes 90% of thyroid disease. Although gluten-free diet may slow progression it won't enable an already damaged thyroid gland to repair or regenerate so you won't be able to regain normal function by diet and you will require daily thyroxine for the rest of your life.

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Ah I get you .thanks .all this is helping me understand the condition .


Lisylou, re cakes, my gf genoise sponge is nicer than the normal one. Because there is no gluten in the gf flour the sponge turns out very tender, while the normal one can be tough if you overmix it. And I make a very nice pie crust w almond meal. :-)


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