I had a partial thyroidectomy in 2011 - one large benign tumour, one small cancerous. Have been on levo since beginning 2013. In 2014 I lost 6 stone with healthy eating, but also lost all by hair and had a lot of other symptoms - levo was increased to 100mg - but my weight loss immediately stalled. I have since been to see endo as TSH was 4.8 and GP and endo have said with previous history of cancer it should not be above 1.5 max. So have been on 125mg for 4 weeks, blood test in 2 weeks, endo again 6 weeks after that - but i have been gradually putting weight back on, mood is low, a lot of joint pain (i have arthritis issues as well) - and ALT has jumped from 41 to 108. Has anyone else had weight gain issues with levo increase?