Yes, for some it can take a month or two. For others, the effect can be felt in just a few days. My niece, who suddenly found herself boo-hooing all the time, short-tempered and depressed, got profound relief in just a few days/weeks. I don't know who was more surprised... her or me. lol.. Her husband was most appreciative since he was the target of most of her moodiness.
Just my opinion, but be careful not to overdue the cream, especially the prescribed medication. For some reason, doctors want to give us mega-doses of progesterone. I have observed where large doses are appropriate and can relieve excessive bleeding, for instance, but for most of us, the 10 mgs daily is plenty.
Taking the pills does require large doses since only about 10% of the prescribed progesterone in the pills survive their trip thru our gut and liver. I often wonder if the docs get confused or think the pills and applying the cream topically are the same?
As always, folks should do their own homework and research. A good book is 'What Your Doctor May Not Tell You About Menopause' by Dr. John Lee.