I have been taking thyroxine for nigh on twenty years and am convinced that it has caused severe weakening of my bones....approx twelve rib fractures in the last eight years... The fact that my condition has not worsened in the last eight years has amazed my doctor but he told me yesterday that full blown osteoporosis is inevitable in the next three years plus. I am currently on 100 mg but at one stage I was on 250 mg which was when my fractures commenced. Has anyone else had a similar experience? Can you offer me any advice on improving my situation? Aged 61, not overweight, regular exerciser and healthy eater.