If you read my responses carefully you'll see that I'm not saying that people without the polymorphism shouldn't receive t3/ndt and/or a combination that suits them. What I am objecting to is you being so dismissive of the effects of the polymorphism.
I believe that hypothyroidism is a more complicated illness than the majority of the medical profession believe and that there is insufficient research into the various factors that predicate how well an individual will respond to treatment.
To date they have identified a single factor that shows a requirement for T3; there may be others as yet unidentified.
By dismissing the effects of the polymorphism as minor you are doing those with it a disservice. Particularly since you're misquoting the paper and stating that only those with the homozygous variant need to take t3 amongst other things.
This forum is supposed to be supportive not to be about 'my symptoms are worse than your's' one upmanship.
One other thing I would note; you've indicated that you react better to t3 and have stated that you haven't actually been tested for the polymorphism. As such how do you know whether your relief of symptoms with t3 is due to the polymorphism or not? One area of research I think would be fruitful would be to test everyone who doesn't do well with t4 only, identify how many have the polymorphism and then to start looking for other common factors in the remainder to see whether other genetic, environmental or other factors could be identified. This would then enable for these to be also tested at diagnosis so that the right treatment pathway could be prescribed.
One thing I'd also note; when you are blithely stating that on 6 micrograms are required by anyone with the polymorphism and providing this as a treatment plan you are making gross assumptions not merely that the person does not have any other factors that affect use of t3 and that dosages in the relatively small study that we're both quoting are correctly titrated.
There is further research on the effect of di02 and t3 that I have read but again I'm on a phone so can't post links easily. These are mainly animal experiments but further support the premise that those of us with the di02 gene snp require t3 to function properly.
So, I'm not saying that you shouldn't campaign for people to receive individualised healthcare as that is a goal that I too strongly support, I'm just asking you not to be so abusive and dismissive of those of us who have the di02 snp. It's misleading to people who may have this and may not have the full information on it plus it's trivialising the suffering of those of us with it that have gone through hell before we received proper treatment.