Interesting article on levotyroxine/synthroid

[Hypo101]

nytimes.com/2001/07/24/scie...

Old but only just come across this.

[diogenes Remembering]

This article shows that have never been formal clinical trials on T4 administration to patients. Therefore there have not been any controlled comparative trials comparing T4 and NDT, which was the treatment before T4 came on the scene. This is a situation that is untenable - all medicines now have to have trials that show their efficacy compared with other alternatives. Combined with bioavailability issues brand to brand for T4, there should be no obstacle to performing a suitable trial T4 v NDT, especially as nowadays the control of NDT formulation is much better than originally. Unfortunately indifference will prevent this from happening, though in present law it should.

[helvella Administrator Thyroid UK]

This is what I referred to the other day (not by this useful link) when someone was dismissing USA "generic" levothyroxine. Synthroid was indeed the late-comer to the party.

Has now passed on, if I remember correctly. to AbbVie.