Neuroprotective actions of thyroid hormones and low-T3 syndrome as a biomarker in acute cerebrovascular disorders

Another paper suggesting that thyroid hormone protects...

Will we see T3 listed in the BNF in every section except endocrinology?

Expert Rev Neurother. 2015 Feb 11:1-12. [Epub ahead of print]

Neuroprotective actions of thyroid hormones and low-T3 syndrome as a biomarker in acute cerebrovascular disorders.

Bunevicius A1, Iervasi G, Bunevicius R.

Author information

1Department of Neurosurgery, Lithuanian University of Health Sciences, Eiveniu g. 2, LT-50009, Kaunas, Lithuania.


Acute cerebrovascular disorders are common causes of death and disability worldwide. Prognostication of stroke victims rests mainly on admission clinical and radiological indexes of disease severity. Preclinical studies strongly suggest that thyroid hormones have a capacity to exert neuroprotective actions in the central nervous system under ischemic conditions via genomic and nongenomic actions. Low triiodothyronine (T3) syndrome affects 32-62% of patients following acute cerebrovascular events. Lower serum T3 concentrations are associated with greater stroke severity, more complicated clinical course, greater mortality rates and elevated risk for poor functional outcomes at discharge and long term. Further studies should address whether T3 can improve clinical stroke prognostication models. Studies investigating the neuroprotective role of thyroid hormone administration in acute cerebrovascular disease victims are encouraged.


biomarker; hemorrhagic stroke; ischemic stroke; low T3 syndrome; outcome; subarachnoid hemorrhage; triiodothyronine




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20 Replies

  • Rod, just like the cardiologists, low T3 has a higher mortality rate, maybe someone should study this, argh. PR

  • PR4Now, and when they do they'll include the usual caveat...but further research is needed!

  • That is huge! And you don't really NEED a doctor to get it.

  • I printed it out to put in my folder of other printed out, pertinent, information..thanks! They have known all of this all along and still leave us undermedicated and ill..dying.

  • Your final comment made me laugh, irony or what! Seriously though a good article Rod, thank you for posting.

  • Rod, thanks for this, very interesting but also depressing! I had asked for T4 and T3 blood tests and was told that the local endo thinks TSH is the only test we need and it is very accurate!!

    I am beginning to wonder if there is a secret agenda, keep us ill, we die off quicker and we can't be a drain on NHS. Sorry if that upsets folk but I do feel like giving up totally.

    Just seen on news that Government wants to get long term sick back to work quicker. I shouted at the box "give 'em the correct medical treatment" Sorry, rant over!

    PS I will get my T3 and T4 privately. We do really have a 2 tier health system, those that can afford to "go off piste" and those that can't.

  • I suspect that they don't want you to die, but they DO want to prescribe all kinds of medications for our problems caused by inadequate thyroid treatment.

    I am on NDT/T3 and don't need asthma clinic any more so two kinds of inhaler and a nebuliser ditched, no statins, no blood thinners, and no regular courses of antibiotics for infections.

    I'm saving the NHS a fortune but my GP was not happy.

    I now see a different one in the same practice, who is much better, but all he can say is, 'well, whatever you are doing you are obviously well, so keep doing it.' BUT does not have the courage to go against the 'guidelines' and prescribe my NDT and T3 for me. Instead he tells me he does not have the expertise. I suppose at least I am grateful that he does not call me stupid like the other one.

    Marie XXX

  • We cannot give up because of obstinate, supposed to be Endocrinologists and doctors.

    This is and explanation between both T3's.

    What is the Difference Between T3 and Free T3?

    Triiodothyronine (T3) is a thyroid hormone that circulates in blood almost completely bound (]99.5%) to carrier proteins. The main transport protein is thyroxine-binding globulin (TBG). However, only the free (unbound) portion of triiodothyronine (free T3) is believed to be responsible for the biological action. Furthermore, the concentrations of the carrier proteins are altered in many clinical conditions, such as pregnancy.

    We cannot give up - they have to be re-educated to be knowledgeable.

  • Ha! Ha! I too shouted at the TV this morning "get their thyroids tested first." crimple.

    Good to hear I am not the only one to do so. :)

  • Thanks for having this rant for me Crimple. This is exactly how I feel and have just been having words with the Pharmacist this morning about rubbish T4 in this country.

  • I am well known for having rants!! Also well known for not giving up. In the past I would have said something re Endo's stance on TSH test, either to endo or GP. I have learnt to keep my mouth shut with them. I just make sure that I get as much as I can from NHS in the way of tests etc and then DIY. All the lovely people on here have given me the confidence to do that. I just get very angry on behalf of those who are too scared or more likley too ill to do anything to improve their situation. I also spot folks on TV, at functions etc and wonder if they have untreated thyroid issues. So far I have been very reserved and said nothing!

    Interested to know about your issue with T4. I was under treated with TEVA 3 years ago and cannot cope with M Pharma, something in the fillers!

  • I am beginning to learn to bite my tongue when I see doctors and Endos now crimple. Am sure my problems are to do with MP Levo that was changed from Goldshield mid 2010. Have just had 8 weeks on teva liquid levo and had to come of it and as a short-term measure go back on Aliud (self-funded). Recently tried Thyroid-S, but my BP went too high. Back on Aliud it has come down to normal (for me), so might give it another try. BP was all over the place on Teva and MP and Wockhardt. Keep on ranting.

  • Interesting that your BP was so affected and very interesting that you have had issues with TEVA and MP. Of course it was only when MHRA flagged up TEVA that I knew something was wrong. I thought it was me! As for MP that deffo gave me palpitations, nausea etc. I don't mind being on a learning curve, but it's all the hoops and obstacles in the way that get to me!

  • Gosh, as someone with low T3 and doctors trying to bully me into lowering my dose of T4, that is very scary (along with all the other studies where they improve non-thyroid-patients' health by giving them T3)!

  • Thanks Rod very much for this link.

    My beloved sister has had one cerebrovascular stroke and now is very disabled indeed (I should say she also has RA). She has gone downhill very gradually. We cannot now converse as we used to talk all the time many hours a week. She is just out of hospital yesterday after her first seizure. She remembers and understands everything and we laugh but our hours of talking we both miss dreadfully.

    When she first had a problem with speech she saw Dr S who prescribed levothyroxine. Her doctor didn't agree (obviously) as she went by blood tests and levo was stopped. Who knows if it was continued, maybe the stroke wouldn't have occurred.

    I have told her family today to ask GP for FT3.

  • Send them the article to take with them, shaws.

  • Thanks. I have done so but I think no matter what you show doctors they just ignore as they follow guidelines. Now that sister is quite unwell they will probably cover their own selves first and foremost.

  • Well in the light of this, they would be unwise to ignore it. And I would tell them to state this in the surgery.

  • I am also going to inform the Rheumatology Dept which were supposed to be caring for her as well and the Cognitive Department as it is far too important to ignore. Many don't read abstracts of anything.

    I also know of another woman who was on levo, also developed a stroke and died last year, previously diagnosed with Alzeimers. Everyone thinks it is apart when it is most probably interconnected.

    How many of us hypo do say we cannot remember, things don't come to the forefront as they used. I am on T3 only myself. How hard it is to get T3 added to T4 when studies show that people do better with the combination.

  • I agree. Humans need to be studied holistically as everything is connected.

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