From the second link "The major active component is the hormone hydrocortisone"
Hydrocortisone is prescribed by doctors for many conditions:
I have had Hashimotos for 10 years and got chronic fatigue 2 years ago. My doctor tested my adrenals using the Genova saliva profile and found that my adrenal function was very low. My doctor initially gave me very small doses of synthetic hydrocortisone as I was unwilling to take the ACE he recommended. He said that ACE is gentler than hydrocortisone which gives a spikier result even taken regularly in small doses. On hydrocortisone I was fine for about an hour after taking it but I had terrible crashes. I increased the doses slowly as per my doctor's instructions but that only made things worse. I had to stop. I was suicidal on hydrocortisone and I was never suicidal before.
After that I started taking ACE which started to work after about 5 days and have been taking it for 2 years. These two years have been more stressful than any time of my life. At the time I quickly built up to 5 capsules of Nutri-Meds ACE (250mg bovine adrenal cortex per capsule). This is no longer available outside the USA so I am now on 1-2 capsules of Adrenavive III which also contains 250mg bovine adrenal cortex per capsule. Adrenavive is made by Procepts Nutrition: procepts.eu
Even though I was very ill with chronic fatigue I had to scrape myself off the floor because a family member got a life-threatening infection which went on for over a year and they were in hospital most of that time. If I hadn't been on ACE I couldn't have done that.
Nutri-Adrenal Extra is made from WHOLE adrenal which contains adrenaline. nutricentre.com/nutri-adren...
Some people like it but from my own exerience I would not recommend any product with adrenaline.
Adrenal cortex extract (ACE) is made from the inner adrenal cortex and does not contain adrenaline.