According to my research (which I did some years ago) taking HRT for menopausal symptoms and also Thyroxine for underactive thyroid, is a real NO NO! Research from a excellent source, probably a USA university, said that if you take HRT for a number of years (usually 5 is the recommended maximum) to help through the menopause, when you come off the HRT your bone thinning will double because of the combined long term effect. I no longer have the reference for this research but can say from personal experience that it is highly likely to be true. I stayed on HRT for 10 years having already been on it for 6 years, because I was afraid to come off it having read this research. I have now been off it for around 18 months and recently had a bone scan. My bones are now extremely thin and verging on osteoporosis whereas a scan 5 years ago showed them to be slightly better than average for my age. I am 63, just about to retire and this has been a real bombshell. Although I am of slight build (a risk factor for osteoporosis) I eat an excellent calcium rich diet, my vit D levels (which is essential for calcium absorption) are normal and I am/have always been very active. I powerwalk a young dog on two fast walks a day of 1 hour each (high impact activity is recommended for bone density) plus train with him and I am on my feet for probably half of the day at least. My doctor has prescibed me high doses of calcium and vit D (I am already getting plenty naturally) and in two weeks will be prescibing me a drug for osteoporosis. So no matter how much you want the supposed benefits of HRT, if you are taking thyroxine (I was on 125-150 a day during that period of my life, now down to 100-125) PLEASE DON'T. Its not worth it the risk!