Yesterday I took my friend for a check-up at the local hospital and it occured to me that the reason why some people don't feel 100% well could be due to auto-immune disease. My friend has lupus and several auto problems although her thyroid is OK. Her symptoms are tiredness, brain fog, gut problems etc. etc. all sound very similar to hypo. The reason I ask the question is could the reason some people don't do well on thyroxin is because of general auto-immune problems some possibly undiagnosed? I know so many people who are not well on thyroxine yet in my own case I don't have any anti-bodies and well fine (thankfully). Should we be approaching auto-immune hypo. from a different direction? My friend needs a lot of meds. but the main one is steroid treatment which seem to control auto-immune response.