I have been on 50mcg of Levo and 13mcg of Tiromel for around six weeks now. Suffering from chronic constipation, then diarrhea, headaches every day, high anxiety and panic. Got to the stage in in bed most of the time, feeling too ill and drained to move. Off work again today and now they want to reduce my hours. I only work four hours a day in a small office. I was prescribed liothyronine by NHS endo for trial, but made me physically I'll, so went back on tiromel. Not sure where to go really - wondered if trying Thyroid-S, a ndt would be a better option? Maybe it's the synthetic stuff that isn't agreeing with me now.