Straining at a camel and producing a gnat

[diogenes]

FYI at TUK there has been recently in Clinical Thyroidal journal a meta- analysis paper on the risk of bone fractures in subclinical hyperthyroidism i.e. TSH's < 0.1 unit with normal FT4. No FT3 mentioned or done. I quote from the paper what I think is the culminating but less than impressive outcome:

Although the HRs for subclinical hyperthyroidism and all outcomes are significantly positive, the absolute excess number of fractures is still relatively small (i.e., 1 excess hip fracture for every 1000 person-years).

OK there is an increased risk but how small! Would you take the risk? I think I know the answer.

[Clutter]

Diogenes, Hardly warrants the dire warnings about low and suppressed TSH causing osteoporosis does it? That very small increased risk is acceptable to me.

[humanbean]

Is there a link available to the meta analysis?

I found this : jama.jamanetwork.com/articl...

but am not sure if it is the paper being referred to. The link I've given is to a whole paper rather than just an abstract.

Edit : Just to make clear to readers - this is not the paper diogenes is referring to. Read further down for the correct one.

[diogenes Remembering in reply to humanbean]

This is the paper quoted:

Leung Angela M.. Clinical Thyroidology. July 2015, 27(7): 174-176. doi:10.1089/ct.2015;27.174-176.

[humanbean in reply to diogenes]

Thank you.

This is the title and a link to the abstract :

"Subclinical Hyperthyroidism Is Associated with Increased Risks of Hip Fractures, Fractures at Any Site, Nonspine Fractures, and Clinical Spine Fractures in the Largest Meta-analysis to Date"

online.liebertpub.com/doi/a...

[TaraJR in reply to humanbean]

humanbean I know this was 7 years ago (!) but I've been looking for this paper for AGES!! It's exactly what I (and others I'm sure) need!

Diogenes quotes above something around "Although the HRs for subclinical hyperthyroidism and all outcomes are significantly positive, the absolute excess number of fractures is still relatively small (i.e., 1 excess hip fracture for every 1000 person-years)."

But your link takes me to a paper I cannot open, not even an abstract. Do you have access to it anywhere else?

This is the link that's posted above that won't let me open the first page

liebertpub.com/doi/full/10....