Zinc over supplementation can cause copper defi... - Thyroid UK

Thyroid UK

141,240 members166,488 posts

Zinc over supplementation can cause copper deficiency

Clutter profile image
11 Replies

Doctors often incorrectly diagnose zinc deficiency, according to a clinical audit in Scotland, and so induce cases of copper deficiency because misplaced treatment results in too much zinc.

Published in the Journal of Clinical Pathology, a publication from The BMJ, the findings come from an analysis of case notes from 70 patients prescribed zinc supplements at Glasgow hospitals in the decade from 2000-10.

The study found that 62% of patients were prescribed zinc at doses sufficient to cause copper deficiency.

"These findings underline the lack of awareness of zinc-induced copper deficiency," conclude the authors. They continue:

"Zinc is an essential trace element and so clinicians may consider it a safe nutrient rather than a drug carrying potential risk.

"This study offers persuasive evidence of a potential risk of iatrogenic copper deficiency being unwittingly caused by prescribing high doses of zinc."

The authors point out that the zinc requirement for adults is less than 10 mg a day. The dose most commonly prescribed, however, is 135 mg a day - yet "there is no evidence to support the prescription of zinc" at this level.

Continued in medicalnewstoday.com/articl...

Written by
Clutter profile image
Clutter
To view profiles and participate in discussions please or .
Read more about...
11 Replies
helvella profile image
helvellaAdministrator

I was scratching my head thinking "How on earth can they prescribe 135 milligrams?", but the BNF clearly shows up to three effervescent tablets a day, each of 45 milligrams.

evidence.nhs.uk/formulary/b...

With not even a mention of copper there.

I find it difficult to understand why the BNF lists it without any real guidance as to dose.

The USA's Office of Dietary Supplements does have consumer and professional sheets:

ods.od.nih.gov/factsheets/Z...

ods.od.nih.gov/factsheets/Z...

Clutter profile image
Clutter in reply tohelvella

Helvella, the article also states that 45mg is the smallest dose [prescription dose] but my supermarket supplement is 15mg, so smaller doses are available.

Justiina profile image
Justiina

Weird indeed as it is known that people who have dentures might end up having sort of zinc poisoning if the paste they use is zinc based.

I have learned that zinc and copper go hand in hand and you need (?) ratio. Always copper taken in morning and zinc before bedtime. Tho recently I have heard that there is supplements that contains both right ratio but that doesn't make sense as they block each other.

Tho this might not be something doctors really know as they seem to know very little about these things. Not even the basics!

Clutter profile image
Clutter in reply toJustiina

Justina, I read that heavy use of dental glue means a lot of zinc may be ingested and causes copper deficiency.

gabkad profile image
gabkad in reply toClutter

Clutter, that stuff was taken off the market.

greygoose profile image
greygoose in reply toJustiina

A ratio of 1:10 copper/zinc.

Chancery profile image
Chancery

I don't know whether this should worry me or not. According to Wikipedia, copper deficiency is very rare, yet I have all of this, to the letter: "The researchers found problems typically associated with zinc-induced copper deficiency: anemia, neutropenia (low white cell count) and/or neurological symptoms developed in 13 patients."

I have low haematocrit anaemia, neutropenia and the neurological condition of trigeminal neuralgia. What's worse, there has never been any explanation of WHY I have neutropenia or low haematocrit, both of which seem to be random and disconnected.

All that said, I see no reason for me to have low copper. I took zinc for many years, through the 80s, 90s, but I haven't taken it since then, so surely it would have corrected itself? The only other thing that MIGHT apply is coeliac disease, which I'm still fighting for the correct testing for, but all the conventional tests have been negative.

Now I don't know if I should risk looking like a (bigger) neurotic fool and ask to have a serum copper test, or this is just too unlikely to be true....

Clutter profile image
Clutter in reply toChancery

Chancery, it seems worth investigating but from what you've said about your GP I don't suppose he'll embrace the possibility. Still, don't ask, don't get.

Chancery profile image
Chancery in reply toClutter

Yep. I think it's that sneering long-suffering reception to the idea that is putting me off asking, but it does seem like a dodgy bunch of coincidences to ignore. I'll feel like the village idiot, but I think I'll just have to be a man and suck it up.

Clutter profile image
Clutter in reply toChancery

Chancery, good luck :)

Chancery profile image
Chancery in reply toClutter

I'll need it - thanks! (And thanks for posting this, as unthrilled as I may be by the prospect!)

Not what you're looking for?

You may also like...

Over range copper and zinc

The only culprit I can think of is milk thistle. Any thoughts on over range copper and zinc?...
Noelnoel profile image

Copper deficiency

Just wondered if anyone is aware of any studies linking copper deficiency with hypothyroidism as I...
JRosemaryW profile image

Country-wide medical records infer increased allergy risk of gastric acid inhibition

A newspaper article and a paper in Nature that raise questions about the effects of Proton Pump...
helvella profile image
Administrator

A Genetic Cause for Iron Deficiency

We see a steady stream of posters here who have iron-deficiency. Iron-deficiency is an important...
helvella profile image
Administrator

Zinc Deficiency

Haven't tested for a long time but with the SIBO going on and not being able to absorb the...
Jefner profile image