Thyroid UK
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Starting on Thyroid-S

I am switching today from Levothyroxine to Thyroid-S and have a plan but would welcome any suggestions to improve it!

I started on Levo over 3 months ago on 25mcg raised to 50mcg about 6 weeks ago. Hypo symptoms have got worse so I guess I'm under-medicated.

However, due to my age and probable long history of hypothyroidism I plan to begin with just half a grain a day (split into 2) for a few days and if no adverse effects raise it to 1 a day which should be more or less equivalent to the dose of Levo I was on.

Then I plan to raise every 2 weeks to eliminate hypo symptoms.

Does this sound like a good plan?

7 Replies

Hi BMG. I think you would be doubling your dose in a matter of days by going to one grain (since 1/2 grain is equal to 50 mcgs. of Levo). The only worry is the T3 in the NDT that your body is not used to having from outside. I think I'd wait more than two days to see how it affects you.

It was probably too slow of inceases with your Levo.


Yet again I got confused and had forgotten what I'd read somewhere! Flippin heck, good job I asked.

Thank you I will start on 1/4 grain a day for a couple of days and then raise to half.


LOL, yes, ask. Five hypos equal one normal brain:)

1 like

An average dose when taking levothyroxine is around 150mcg some much more, so you were underdosed on levothyroxine. Whatever medication you take it has to be, eventually, an optimum dose.

Half a grain of NDT is equal approx to 50mcg, so why split the dose? I believe that all NDT tablets are made to be taken once daily. I do know some split, but it is the T3 which has to 'saturate' our cells to enable our metabolism to be raised sufficiently for us to feel well.

I hope you feel better soon.

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Thank you, Shaws... I think I must have muddled up advice on taking NDT and T3 :-( I will take them once a day, then.


Bobsmydog you haven't muddled the advice. Most people introduce T3/NDT in 2 daily doses until they see how they tolerate it. Some are sensiive and it can be easier to handle in two split doses as it spreads the effect a little more smoothly. Others feel the T3 wears off unless they split dose 6-12 hours apart. It's suck it and see to find what suits you. Advice is generally to start on half a grain, hold for one/two weeks and then increase by half grain increments until symptoms resolve or on 2 grains and then hold on 2 grains for 4 weeks and have a blood test to check levels before increasing further.


Thank you :-)


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