Hi everyone. My friend has been on 50mcg for 10 years, never had an increase. Her sister after persisting for two years has just been diagnosed at a TSH if 6.5. She's been feeling tired and unwell for about a year she had a full hysterectomy recently so I know that takes its toll. I asked her to give me recent blood results and they were TSH 4.74 and T4 11.4. No wonder she feels poorly I said. She asked her GP for increase and was refused saying it's her not taking HRT that's the problem. Worth pointing out she did take her levo on morning of test so her TSH is probably higher than that. I don't understand what affect HRT and not taking it would have on thyroid etc?