I was diagnosed with hashimotos a few years ago. My endo has slowly been increasing my meds. Synthroid 100mg which I have been taking for a few years now. My doctor was finally starting to get my tsh within range around 0.50 and was going to see me again to re-evaluate in another 6 months. But I insisted 6 weeks. Glad I did. My tsh has spiked up to 11.494 (0.300-5.000) and my T4 is 12.0 (9.0-24.0) the doctor was baffled and told me to not eat anything for 4 hours after taking my meds and we will recheck everything in 2 months. If my doctor is confused any ideas or personal experiences what might be going on? I m tired, cold, my hair and nails are dry and brittle, muscle fatigue, out of breath. No weight gain though. I also am experiencing bouts of depression mixed with anxiety.