At last, our paper on the disjoints between T4 therapy, T3 and TSH response is accepted in Hormone & Metabolic Research. This sentence might sum it all up: "Regulatory and capacity deficiencies collectively impair T3 homeostasis in L-T4-treated patients". In other words T4 mono therapy is an artificial and inadequate therapy for at least some hypothyroid patients especially those with little or no remaining thyroid who are also poorer natural tissue/T4-T3 converters. There is a lot more in the text supporting this. Next in line is coming down from Mount Olympus (i.e. academic ivory tower) to relating our findings to diagnostic and therapeutic indications for adequate treatment, and the relationship of this to how individuals convert T4 to T3 in their tissues and the relationship between thyroid T3 output and tissue conversion of T4. This needs yet another carefully planned trial. In short, trying to integrate what you already know with rigid scientific findings. The only way I fear to respectability and more general acceptance.