T3 and sleep

I have been on t3 for 10 days and not yet noticed any difference. One cause may be that I am now consistently waking in the night. I fall asleep easily about 11 pm but finding that I am awake again about 3 o'clock for 2-3 hours. This is causing me to be so tired that I am sure it is negating any good the medication is doing.

Anyone else had a similar problem or got any ideas how I can try to stay asleep?

Many thanks for any help.

9 Replies

  • It would be a good idea to add some detail about how much you are taking, when, and any other medicines (are you still taking levothyroxine as well?). Those who have experience would then be better placed to make some suggestions.


  • Good idea. Was taking 10mg on waking increased to 20 mg 2 days ago split morning no lunch time. No Levo only nutri adrenal extra and nutri thyroid. Vit tablets.

  • That is meant to say vit d!

  • This is a link re T3. This is an excerpt:-

    This information is accurate—when plain, full-strength, one-time-per-day doses of T3 are used properly, there are no adverse effects. The only adverse effects occur when a patient takes a dosage that for her is excessive. With Cytomel, if overstimulation occurs, it can be stopped with one or two small doses of propranolol. Or the patient can simply reduce her dosage of Cytomel the next time she takes it. I want to emphasize, however, that when our protocol is used properly, there is no overstimulation to be avoided by using timed-release T3. The protocol has safeguards against adverse effects.

    And finally, why do I specify that the typical patient use one full dose of non-timed-release Cytomel for life? Because extensive testing has shown that this is safe, effective, and most economical—when used within the context of our entire protocol.


    I would take any other supplements/medications 4 hours apart from T3.

  • Thanks shaws but just to be clear are you saying that I shouldn't split the dose but take it all in the morning?

  • That's what was part of Dr Lowe's protocol for his patients and I have always taken mine in one dose, whether T4, T4/T3, NDT or T3. I cannot be bothered to remember or carrying pills around (alarms) and I want to feel normal and free but more importantly I am well. I haven't been overstimulated (i.e. taken too much) but as Dr L says, just miss or reduce next day's dose.

  • When I took T3 only I took a tiny dose (quarter of a tablet) just before I went to sleep and it helped me to stay asleep longer.

    I think you might be waking up because your body runs out of T3 during the night.

    This night-time dose works for some but not others. The only thing you can do is experiment and see if it works for you.

  • Churchie, I take T4 + 10mcg T3 in the morning and the second dose T3 20mcg at bedtime. Try shifting your second dose 2/4 hours later to see whether that improves sleep or try it at bedtime.

  • I find that when I wake in the night it is normally a result of being undermedicated, I rarely take a dose later than 6pm. I originally split mine into 4 doses. now on 2-3 depending on my needs. for me on t3 only this works for me and gives me consistency without peaks and troughs.


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