Would B12 affect test for antibodies?

Hi! I'm currently pondering trying to get my GP to test for antibodies for pernicious anaemia (latest blood showed B12 serumcobalamin at 248 (180-2000) ) but in the meantime, if I supplement that will change B12 levels.. But would it change the antibodies? If they are still there, surely that would give them the info needed?

Plus I am happy to say I read that oral supplements have recently been shown to be as effective as injections, yay!

5 Replies

The question of whether oral supplements are as effective as injections depends on the person. If you just cannot absorb B12 in the stomach due to pernicious anaemia, oral supplements won't be effective. The success of sublingual supplements seems to vary from person to person too. It would definitely be a good idea to get antibodies checked but I'm afraid I don't know enough about these tests to know if taking B12 supplements would affect them.

There are a few people in this community who know a lot about B12 and pernicious anaemia and certainly far more than me. It might also be worth looking at the Pernicious Anaemia Society website for further information.

I hope you get the answers you need.

Carolyn x

Oh thank you! I never thought of that! Will go and check the PA website :)

If you don't find what you need, hopefully the people knowledgeable about b12 will be along soon :)

I have pernicious anaemia and, thankfully, for me was discovered before any symptoms showed. I had a test called the Schilling test but that has been discontinued . It showed if your red blood cells were enlarged and therefore, it was the stomach that was changing and when it does it cannot absorb vitamin B12 from food which would eventually cause serious health issues. As does B12 deficiency.

I have now been told it is difficult nowadays to differentiate between low B12 (deficiency) and PA. In any case, supplementation with sublingual B12 methylcobalamin tablets or B12 injections but you must first be diagnosed properly. This is a link:


This is a link which gives us info the medical profession dont.


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